each one of the three CrGPDHs has a bi-domain protein structure: a GPDH domain of about 350 amino acids located at the C terminus, and a phosphoserine phosphatase (SerB) domain of about 200 amino acids at the N terminus. The GPDH domain of all three CrGPDHs contains the conserved GSGAWA motif at residues 261-266 (CrGPDH1), 316-321 (CrGPDH2), and 267-272 (CrGPDH3), three-dimensional structures by homology modeling, based on the Homo sapiens GPD1 crystal structure, overview
each one of the three CrGPDHs has a bi-domain protein structure: a GPDH domain of about 350 amino acids located at the C terminus, and a phosphoserine phosphatase (SerB) domain of about 200 amino acids at the N terminus. The GPDH domain of all three CrGPDHs contains the conserved GSGAWA motif at residues 261-266 (CrGPDH1), 316-321 (CrGPDH2), and 267-272 (CrGPDH3), three-dimensional structures by homology modeling, based on the Homo sapiens GPD1 crystal structure, overview
the enzyme monomer is organized with N- and C-terminal domains. The N-terminal domain contains a classic Rossmann fold with the (beta-alpha-beta-alpha-beta)2 motif typical of many NAD+-dependent enzymes, while the C-terminal domain is mainly alpha-helical, structure comparisons, overview
three-dimensional structure modeling of enzyme G3PDH to identify the potential phosphorylation site Tyr83 responsible for the differential phosphorylation between euthermic and hibernator G3PDH, predicted tertiary and quaternary structures, overview