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17beta-estradiol + NADP+
estrone + NADPH
5beta-androstane-3alpha,17beta-diol + NADP+
5beta-androstane-3alpha-ol-17-one + NADPH + H+
-
-
-
r
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
androstenedione + NADPH + H+
testosterone + NADP+
testosterone + NAD+
androst-4-ene-3,17-dione + NADH + H+
-
NADP+ is preferred
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
testosterone + NADP+
androstenedione + NADPH + H+
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
17beta-estradiol + NADP+
estrone + NADPH
-
-
-
r
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
-
the enzyme plays a central role in the development of the male phenotype. Mutations that inactivate the enzyme give rise to a rare form of male pseudohermaphroditism, referred to as 17beta-HSD-3 deficiency
-
-
?
androst-4-ene-3,17-dione + NADPH
testosterone + NADP+
-
convertion of the weak androgen androstendione into the potent androgen testosterone
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
the enzyme is involved in biosynthesis of testosterone
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
-
-
-
-
?
androstenedione + NADPH + H+
testosterone + NADP+
the two reactions 11beta-HSD1-dehydrogenase, EC 1.1.1.146, and 17beta-HSD3, EC 1.1.1.64, which utilize NADPH are competing for NADPH from the same cofactor pool. 11beta-HSD1-dehydrogenase serves as a NADPH-regenerating system that is tightly coupled in regulating 17beta-HSD3 reaction synthesizing testosterone. A cycle can exist whereby the NADPH produced by 11beta-HSD1 dehydrogenase can drive the reductase activity of 17beta-HSD3 and the NADP+ produced by 17beta-HSD3 and other enzymes involved in testosterone biosynthesis can drive the dehydrogenase activity of 11beta-HSD1
i.e. 4-androsten-17beta-ol-3-one
-
?
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
17beta-hydroxysterod dehydrogenase 3, reduction of androst-4-ene-3,17-dione is preferred
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androst-4-ene-3,17-dione + NADPH + H+
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
-
r
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
?
testosterone + NADP+
androstenedione + NADPH + H+
-
-
-
?