1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-HSD5, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, HSD17B3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)

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Results	in table
1	Activating Compound
24	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
57	Cofactor
6	Crystallization (Commentary)
31	Disease/ Diagnostics
5	Expression
17	General Information
1	General Stability
114	IC50 Value
231	Inhibitors
1	kcat/KM [mM/s]
12	Ki Value [mM]
31	KM Value [mM]
23	Localization
9	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
65	Organism
7	Pathway
52	PDB ID
12	pH Optimum
2	pH Range
16	Protein Variants
7	Purification (Commentary)
3	Reaction
3	Reaction Type
65	Reference
78	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
112	Substrates and Products (Substrate)
1	Subunits
65	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Expression

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Expression on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

curcumin analog H10 inhibits the production of 17beta-HSD3 in vitro. It has no effect on the expression levels of 17beta-HSD3, 3betaHSD1, CYP17alpha1, CYP11alpha1, and STAR. H10 could serve as an effective inhibitor of 17beta-HSD3, which in turn would inhibit the biosynthesis of androgens and progression of prostate cancer

Homo sapiens

P37058

761168

exposure of HCT-15 cells to cisplatin results in aquisition of cisplatin resistance and concomitant induction of isoform AKR1C3 and aldo-keto reductase AKR1C1 expression

Homo sapiens

P42330

724719

in thrombocythemia, a rare myeloproliferative disorder, 17beta-HSD3 is down-regulated about 4.5fold

Homo sapiens

P37058

762479

the enzyme (17beta-HSD3) is over-expressed in hormone-dependent prostate cancer. 17beta-HSD3 mRNA increases over 30fold in cancerous prostate biopsies and the enzyme is overexpressed 8fold in LuCaP-23 and LuCAP-35 cell lines, obtained from metastatic tissues of a patient resistant to castration therapy

Homo sapiens

P37058

762479

the expression of isoform AKR1C3 is reduced in both hyperplastic and carcinomatous endometrial epithelium

Homo sapiens

P42330

725152