Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.62: 17beta-estradiol 17-dehydrogenase

This is an abbreviated version!
For detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.62

Reaction

17beta-estradiol
+
NAD(P)+
=
estrone
+
NAD(P)H
+
H+

Synonyms

(17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-hsd 14, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD10, 17beta-HSD12, 17beta-HSD14, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 1, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 10, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 14, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase type IV, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, 7beta-HSD7, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, aldo-keto reductase 1B15, C6Y55_RS00895, C6Y55_RS01070, C6Y55_RS01190, C6Y55_RS15130, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, HSD17B7, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, NlHsd17b12, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, reductive 17beta-hydroxysteroid dehydrogenase type 7, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.62 17beta-estradiol 17-dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
17beta-estradiol + NAD(P)+
estrone + NAD(P)H + H+
show the reaction diagram
17beta-estradiol + NAD+
estrone + NADH + H+
show the reaction diagram
17beta-estradiol + NADP+
estrone + NADPH
show the reaction diagram
-
-
-
-
?
17beta-estradiol + NADP+
estrone + NADPH + H+
show the reaction diagram
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
show the reaction diagram
-
17beta-HSD3 and 5, formation of active androgens in testis and prostate
-
-
?
4-estrene-3,17-dione + NADPH
4-estrene-17beta-ol-3-one + NADP+
show the reaction diagram
-
-
-
-
r
5alpha-androstane-3alpha,17beta-diol + NAD+
androsterone + NADH + H+
show the reaction diagram
-
-
-
?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
show the reaction diagram
the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells
-
-
?
androstenedione + NAD(P)H + H+
testosterone + NADP+
show the reaction diagram
-
-
-
?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H
show the reaction diagram
-
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
-
-
?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H + H+
show the reaction diagram
-
17beta-HSD4 is involved in etsrogen inactivation and may protect against an excessive accumulation of E2 in human ovarian epithelial cells
-
-
?
estradiol-17beta + NAD+
estrone + NADH
show the reaction diagram
-
-
-
-
?
estradiol-17beta + NAD+
estrone + NADH + H+
show the reaction diagram
-
vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Vitamin K2 decreases the estradiol-17beta/estrone ratio in cells by 25%
-
-
?
estradiol-17beta + NADP+
estrone + NADPH
show the reaction diagram
-
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity
-
-
?
estrogenic estrone + NAD(P)H + H+
17beta-estradiol + NAD(P)+
show the reaction diagram
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases
-
-
?
estrone + NAD(P)H
estradiol + NAD(P)+
show the reaction diagram
-
normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
-
-
?
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
show the reaction diagram
estrone + NAD(P)H + H+
estradiol + NAD(P)+
show the reaction diagram
estrone + NAD(P)H + H+
estradiol-17beta + NAD(P)+
show the reaction diagram
-
type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol
-
-
?
estrone + NADH
estradiol-17beta + NAD+
show the reaction diagram
estrone + NADH + H+
17beta-estradiol + NAD+
show the reaction diagram
-
-
-
?
estrone + NADPH
17beta-estradiol + NADP+
show the reaction diagram
estrone + NADPH + H+
17beta-estradiol + NAD(P)+
show the reaction diagram
steroid hormone pathway
-
-
?
estrone + NADPH + H+
17beta-estradiol + NADP+
show the reaction diagram
estrone + NADPH + H+
estradiol-17beta + NADP+
show the reaction diagram
estronesulfate + NADPH
17beta-estradiolsulfate + NADP+
show the reaction diagram
-
-
-
-
r
testosterone + NAD(P)+
4-androstene-3,17-dione + NAD(P)H
show the reaction diagram
-
17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
-
-
?
testosterone + NAD+
androst-4-ene-3,17-dione + NADH + H+
show the reaction diagram
-
-
-
?
testosterone + NAD+
androstenedione + NADH + H+
show the reaction diagram
testosterone + NAD+
DELTA4-3,17-androstendione + NADH + H+
show the reaction diagram
-
-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
show the reaction diagram
-
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens
-
-
?
additional information
?
-