1.1.1.62: 17beta-estradiol 17-dehydrogenase This is an abbreviated version! For detailed information about 17beta-estradiol 17-dehydrogenase, go to the full flat file .
Reaction
17beta-estradiol +
NAD(P)+ =
estrone +
NAD(P)H +
H+
Synonyms (17beta-HSD) type 1, (17beta-HSD) type 2, 17-beta-HSD 2, 17-beta-hydroxysteroid dehydrogenase type 12, 17-beta-hydroxysteroid dehydrogenase type 2, 17-HOR, 17-HSD, 17beta HSD1, 17beta,20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, 17beta-HSD, 17beta-hsd 14, 17beta-HSD I, 17beta-HSD type 1, 17beta-HSD type 12, 17beta-HSD type 2, 17beta-HSD type 4, 17beta-HSD type 5, 17beta-HSD type 7, 17beta-HSD type 8, 17beta-HSD1, 17beta-HSD10, 17beta-HSD12, 17beta-HSD14, 17beta-HSD2, 17beta-HSD4, 17beta-HSD5, 17beta-HSD7, 17beta-HSD7 2, 17beta-HSDcl, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 1, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase 4, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 10, 17beta-hydroxysteroid dehydrogenase type 12, 17beta-hydroxysteroid dehydrogenase type 14, 17beta-hydroxysteroid dehydrogenase type 2, 17beta-hydroxysteroid dehydrogenase type 4, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenase type 6, 17beta-hydroxysteroid dehydrogenase type 7, 17beta-hydroxysteroid dehydrogenase type 8, 17beta-hydroxysteroid dehydrogenase type I, 17beta-hydroxysteroid dehydrogenase type IV, 17beta-hydroxysteroid dehydrogenase types 1, 17beta-hydroxysteroid dehydrogenases type 1, 17betaHSD, 17betaHSD1, 17betaHSD14, 17betaHSD6, 17HSD1, 20 alpha-hydroxysteroid dehydrogenase, 20-alpha-HSD, 20alpha-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-hydroxysteroid dehydrogenase, 3betaHSD, 7beta-HSD type 1, 7beta-HSD7, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, aldo-keto reductase 1B15, C6Y55_RS00895, C6Y55_RS01070, C6Y55_RS01190, C6Y55_RS15130, dehydrogenase, estradiol 17beta-, E2DH, EDH, estradiol 17beta-dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, estrogenic 17beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD17B1, HSD17B12, HSD17B2, HSD17B4, HSD17B7, hydroxysteroid (17-beta) dehydrogenase 1, Ke6 protein, mf17beta-HSD12, microsomal 17-beta-hydroxysteroid dehydrogenase, More, NlHsd17b12, oestradiol-17beta hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, PRAP, PRL receptor associated protein, reductive 17beta-hydroxysteroid dehydrogenase type 7, testicular 17-beta-hydroxysteroid dehydrogenase, type 1 17beta-HSD, type 1 17beta-hydroxysteroid dehydrogenase, type 12 17beta-HSD, type 12 17beta-hydroxysteroid dehydrogenase, type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase, type 5 17-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase, type 7 17beta-hydroxysteroid dehydrogenase, type 8 17beta-HSD, type 8 17beta-hydroxysteroid dehydrogenase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase
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17beta-estradiol + NAD(P)+
estrone + NAD(P)H + H+
17beta-estradiol + NAD+
estrone + NADH + H+
17beta-estradiol + NADP+
estrone + NADPH
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-
-
-
?
17beta-estradiol + NADP+
estrone + NADPH + H+
4-androstene-3,17-dione + NADPH + H+
testosterone + NADP+
-
17beta-HSD3 and 5, formation of active androgens in testis and prostate
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?
4-estrene-3,17-dione + NADPH
4-estrene-17beta-ol-3-one + NADP+
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-
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r
5alpha-androstane-3alpha,17beta-diol + NAD+
androsterone + NADH + H+
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?
5alpha-dihydrotestosterone + NADP+
5alpha-androstan-3,17-dione + NADPH
the enzyme could play a critical role in estrogen-sensitive cells, since it inactivates 5alpha-dihydrotestosterone that generally shows antagonistic effect in the cells
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?
androstenedione + NAD(P)H + H+
testosterone + NADP+
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?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H
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17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
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?
estradiol-17beta + NAD(P)+
estrone + NAD(P)H + H+
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17beta-HSD4 is involved in etsrogen inactivation and may protect against an excessive accumulation of E2 in human ovarian epithelial cells
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?
estradiol-17beta + NAD+
estrone + NADH
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?
estradiol-17beta + NAD+
estrone + NADH + H+
-
vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism. Vitamin K2 decreases the estradiol-17beta/estrone ratio in cells by 25%
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?
estradiol-17beta + NADP+
estrone + NADPH
-
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity
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?
estrogenic estrone + NAD(P)H + H+
17beta-estradiol + NAD(P)+
the product 17beta-estradiol plays a central role in the etiology of estrogen dependent diseases
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?
estrone + NAD(P)H
estradiol + NAD(P)+
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normal and tubal pregancies possess identical expression of 17HSD1 in syncytiotrophoblast cells and therefore, similar estradiol production in the placenta. Association of 17HSD1 with extravillous cells indicates that the enzyme perhaps plays a role in trophoblast invasion.Increased expression of 17HSD1 in epithelial cells of fallopian tube may lead to a local estradiol supply sufficient for maintenance of tubal pregnancy
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?
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
estrone + NAD(P)H + H+
estradiol + NAD(P)+
estrone + NAD(P)H + H+
estradiol-17beta + NAD(P)+
-
type 1 17beta-hydroxysteroid dehydrogenase plays a critical role in the biosynthesis of estradiol
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?
estrone + NADH
estradiol-17beta + NAD+
estrone + NADH + H+
17beta-estradiol + NAD+
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-
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?
estrone + NADPH
17beta-estradiol + NADP+
estrone + NADPH + H+
17beta-estradiol + NAD(P)+
steroid hormone pathway
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?
estrone + NADPH + H+
17beta-estradiol + NADP+
estrone + NADPH + H+
estradiol-17beta + NADP+
estronesulfate + NADPH
17beta-estradiolsulfate + NADP+
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-
-
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r
testosterone + NAD(P)+
4-androstene-3,17-dione + NAD(P)H
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17beta-HSD2 and 5, key role in regulating steroid receptor occupancy in normal and tumor tissues
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?
testosterone + NAD+
androst-4-ene-3,17-dione + NADH + H+
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-
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?
testosterone + NAD+
androstenedione + NADH + H+
testosterone + NAD+
DELTA4-3,17-androstendione + NADH + H+
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-
-
?
testosterone + NADP+
4-androstene-3,17-dione + NADPH + H+
-
17beta-HSD2, important role in peripheral inactivation of androgens and estrogens
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?
additional information
?
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17beta-estradiol + NAD(P)+
estrone + NAD(P)H + H+
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-
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r
17beta-estradiol + NAD(P)+
estrone + NAD(P)H + H+
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-
-
r
17beta-estradiol + NAD(P)+
estrone + NAD(P)H + H+
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-
r
17beta-estradiol + NAD+
estrone + NADH + H+
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-
r
17beta-estradiol + NAD+
estrone + NADH + H+
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-
-
r
17beta-estradiol + NAD+
estrone + NADH + H+
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?
17beta-estradiol + NAD+
estrone + NADH + H+
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-
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?
17beta-estradiol + NAD+
estrone + NADH + H+
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?
17beta-estradiol + NAD+
estrone + NADH + H+
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-
?
17beta-estradiol + NAD+
estrone + NADH + H+
ANI02794.1
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?
17beta-estradiol + NAD+
estrone + NADH + H+
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?
17beta-estradiol + NAD+
estrone + NADH + H+
ANI02794.1
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?
17beta-estradiol + NADP+
estrone + NADPH + H+
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?
17beta-estradiol + NADP+
estrone + NADPH + H+
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-
?
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
-
final step in the synthesis of active estrogens
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r
estrone + NAD(P)H
estradiol-17beta + NAD(P)+
the enzyme produces active estradiol for cell proliferation
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?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
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?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
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?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
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?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
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17beta-hydroxysteroid dehydrogenase has a pivotal role in regulating the synthesis of estradiol within breast tumours. 17beta-hydroxysteroid dehydrogenase activity contributes to the high estradiol concentrations found in most breast tumours
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?
estrone + NAD(P)H + H+
estradiol + NAD(P)+
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the enzyme efficiently converts estrone to estradiol and enhances the estrogen-dependent growth of cultured MCF-7 cells in the presence of hormonally less active estrone. The reaction is reversible in vitro, but in cultured cells the production of estradiol is the predominant rection in physiological conditions
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r
estrone + NAD(P)H + H+
estradiol + NAD(P)+
type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause
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?
estrone + NADH
estradiol-17beta + NAD+
key enzyme responsible for elevated levels of 17beta-estradiol in breast tumor tissues
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?
estrone + NADH
estradiol-17beta + NAD+
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exposure to epidermal growth factor slowly induces a cellular state in which enzyme activity is subject to modulation by both progesterone and estradiol
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?
estrone + NADH
estradiol-17beta + NAD+
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17beta-estradiol is a potent stimulator of certain endocrine-dependent forms of breast cancer. The enzyme catalyzes the last step in the biosynthesis of 17beta-estradiol from the less potent estrogen, estrone
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?
estrone + NADH
estradiol-17beta + NAD+
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type 1 enzyme, catalyzes the conversion of the low activity estrogen, estrone, into highly active estradiol, both in the gonads and in target tissues
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?
estrone + NADH
estradiol-17beta + NAD+
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the reductive activity predominates in hormone dependent breast tumors. This gives rise to high concentrations of estradiol in breast cancer
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?
estrone + NADH
estradiol-17beta + NAD+
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trans-retinoic acid increases expression of the enzyme in a dose-dependent and time-dependent manner in T47D breast cancer cells, the increased expression is associated with an increase in reductive activity of the enzyme
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?
estrone + NADH
estradiol-17beta + NAD+
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progesterone treatment of ovariectomized gilts stimulates oxidative activity in uterus, anterior pituitary, skeletal muscle and kidney, constitutive levels of activity in adrenals, lung and liver
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?
estrone + NADPH
17beta-estradiol + NADP+
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r
estrone + NADPH
17beta-estradiol + NADP+
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convertion of the weak androgen estrone into the potent estrogen 17beta-estradiol
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?
estrone + NADPH
17beta-estradiol + NADP+
-
isozyme 17beta-HSD1
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?
estrone + NADPH
17beta-estradiol + NADP+
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the reversible reaction constitutes an important pre-receptor control mechanism for nuclear receptor ligands, since the conversion switches between the 17beta-hydroxy receptor ligands and their inactive 17-oxo metabolites
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r
estrone + NADPH
17beta-estradiol + NADP+
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type 8 17beta-HSD can downregulate 17beta-estradiol levels in a large variety of tissues
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?
estrone + NADPH + H+
17beta-estradiol + NADP+
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?
estrone + NADPH + H+
17beta-estradiol + NADP+
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?
estrone + NADPH + H+
17beta-estradiol + NADP+
most active enzyme in regards to 17beta-estradiol production
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?
estrone + NADPH + H+
estradiol-17beta + NADP+
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final step in the synthesis of active estrogens
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?
estrone + NADPH + H+
estradiol-17beta + NADP+
final step in the synthesis of active estrogens, important in the maintenance of pregnancy
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?
estrone + NADPH + H+
estradiol-17beta + NADP+
final step in the synthesis of active estrogens, important in the maintenance of pregnancy
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-
r
estrone + NADPH + H+
estradiol-17beta + NADP+
-
17beta-HSD1, final step in the synthesis of active estrogens
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-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
final step in the synthesis of active estrogens
-
-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens, maintenance of a proper balance of inactive estrone and active estradiol-17beta in brain
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?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in synthesis of estradiol
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-
?
estrone + NADPH + H+
estradiol-17beta + NADP+
-
final step in the synthesis of active estrogens
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?
estrone + NADPH + H+
estradiol-17beta + NADP+
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related to nuclear maturation in oocytes
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?
testosterone + NAD+
androstenedione + NADH + H+
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?
testosterone + NAD+
androstenedione + NADH + H+
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-
?
additional information
?
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the isozymes constitute by showing different properties a complex system ensuring cell-specific adaptation and regulation of sex steroid hormone levels, isozyme 17beta-HSD1 is the major determinant of peripheral and gonadal estradiol synthesis
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?
additional information
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expression is stimulated 2fold by dexamethasone but is completly downregulated by phorbol ester
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?