Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

1.1.1.51: 3(or 17)beta-hydroxysteroid dehydrogenase

This is an abbreviated version!
For detailed information about 3(or 17)beta-hydroxysteroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.51

Reaction

testosterone
+
NAD(P)+
=
androstenedione
+
NAD(P)H
+
H+

Synonyms

17 beta-HSD3, 17 beta-hydroxysteroid dehydrogenase, 17-beta-HSD, 17-ketoreductase, 17beta-HSD, 17beta-HSD (type 1), 17beta-HSD (type 3), 17beta-HSD type 2, 17beta-HSD type 3, 17beta-HSD type II, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD2, 17beta-HSD3, 17beta-HSD5, 17beta-HSD7_2, 17beta-HSOR, 17beta-hydroxy steroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 2, 17beta-hydroxysteroid dehydrogenase type 1, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenases, 17beta-hydroxysteroid dehydrogenases type 2, 17beta-hydroxysteroid oxidoreductase, 17beta-hydroxysteroid: NADP 17-oxidoreductase, 17betaHSD2, 3 beta-hydroxysteroid dehydrogenase, 3,17beta-HSD, 3,17beta-hydroxysteroid dehydrogenase, 3-beta HSD, 3beta,17beta-hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD (type 1), 3beta-HSD type-I, 3beta-HSD type-II, 3beta-HSD/isomerase, 3beta-hydroxy steroid dehydrogenase, 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase/DELTA5-4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxystroid oxidoreductase, 3beta/17beta-HSD, 3beta/17beta-hydroxysteroid dehydrogenase, 3beta17betaHSDH, 3betaHSD, AKR1C3, AKR1C35, aldo keto reductase 1C3, beta-hydroxy steroid dehydrogenase, betahsd, dehydrogenase, 17beta-hydroxy steroid, dehydrogenase, 3beta-hydroxy steroid, dehydrogenase, beta-hydroxy steroid, DELTA5-3beta-HSD, DELTA5-3beta-hydroxysteroid dehydrogenase, form 2 type 7 17beta-hydroxysteroid dehydrogenase, HSD, HSD17B1, HSD17B3, LOC101842245, More, pQ3 beta HSD, RDH11, Rdh11/12-like 1, Rdh11/12-like 2, Rdh11/12-like 3, retinol dehydrogenases 11-like, steroid 17beta-reductase, type 17beta-HSD, type 2 17beta-HSD, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17-beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase

Expression

Expression on EC 1.1.1.51 - 3(or 17)beta-hydroxysteroid dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
3,17beta-HSD gene expression is induced by testosterone, but not by estradiol and cholesterol
3beta-HSD is suppressed by vitamin D, about 20% at the enzyme activity level and 60% at the mRNA level
-
downregulation of CX3CL1, EPHB6, and TP63 increases HSD17B1 and HSD17B2 expression
estradiol and cholesterol both cannot induce betahsd gene expression in both wild-type and mutant Comamonas testosteroni
estradiol negatively regulates HSD17B1 in breast cancer cell lines. Dihydrotestosterone has a primarily reductive impact on HSD17B1 expression
GREB1 downregulation suppresses HSD17B1
in non-small cell lung cancer (NSCLC) the expression of HSD17B1 is increased as compared with healthy tissue
miRNA-1304-3p reduces HSD17B1 expression
miRNA-17 upregulates HSD17B1
miRNA-210 and miRNA-7-5p have up- and down-regulatory effect
recombinant equine gonadotropins (reFSH and reLH) and 11-oxotestosterone (11KT) have no effects on the expression of rdh11/12-like transcripts in the testis
-
the enzyme expression is induced by testosterone
the transcriptional repressor phaR gene (phaR) locates 2290 bp upstream of the betahsd gene and might bind on a special bhsd promoter domain