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1.1.1.49: glucose-6-phosphate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.49

Reaction

D-glucose 6-phosphate
+
NADP+
=
6-phospho-D-glucono-1,5-lactone
 +
NADPH
 +
H+

Synonyms

6-phosphoglucose dehydrogenase, beta-D-glucose-6-phosphate; NADP oxidoreductase, beta-D-glucose-6-phosphate;NADP oxido-reductase, D-glucose 6-phosphate dehydrogenase, D-glucose 6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate: NADP+ oxidoreductase, D-glucose-6-phosphate:NADP oxidoreductase, Entner-Doudoroff enzyme, G-6-PD, G-6-PDH, G-6PD, G6PD, G6PD1, G6PD2, G6PD3, G6PD4, G6PD5, G6PD6, G6PDH, G6PDH-1, G6PDH-2, G6PDH1, G6PDH2, G6PDH3, G6PDH4, G6PDH5, G6PDH6, Glc6PDH, glucose 6-phosphate dehydrogenase, glucose 6-phosphate dehydrogenase (NADP), glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase, GPD, KlZWF1, NADP-dependent glucose 6-phophate dehydrogenase, NADP-glucose-6-phosphate dehydrogenase, P2-G6PDH, PF14_0511, PfGluPho, plastidial glucose 6-phosphate dehydrogenase, VEG11, Vegetative protein 11, Zwf, zwf-1, Zwf-2, Zwf1p, Zwischenferment

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.49 glucose-6-phosphate dehydrogenase (NADP+)

Source Tissue

Source Tissue on EC 1.1.1.49 - glucose-6-phosphate dehydrogenase (NADP+)

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
G6PD is more than 2fold higher in pulmonary arteries compared with coronary arteries
Manually annotated by BRENDA team
-
glucose-6-phosphate dehydrogenase plays a central role in modulating reduced glutathione levels in reed callus under salt stress
Manually annotated by BRENDA team
-
of vile ducts and blood vessel walls in portal tracts
Manually annotated by BRENDA team
-
G6PD deficiency is associated with premature senescence of human fibroblasts
Manually annotated by BRENDA team
-
enzyme is stimulated in presence of 3 mg and 5 mg of Cd on the first day of experiment in gill, liver and kidney tissues. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished after seven days. The G6PD enzyme activity levels are stimulated by approximately 60% in gills
Manually annotated by BRENDA team
-
resident liver macrophage, from sinusoidal lumen
Manually annotated by BRENDA team
-
in patients with type 1 diabetes G6PDH activity does not differ from control group, but enzyme activity is sharply decreased in pregnant women with type 2 diabetes and gestational diabetes
Manually annotated by BRENDA team
-
pregnant women, G6PD translocates to microtubule-organizing centers
Manually annotated by BRENDA team
-
moderate overexpression of the enzyme (G6PD) can protect beta-cells from age-associated oxidative stress thus reducing the risk of developing type 2 diabetes. The animal show an improved glucose tolerance and insulin sensitivity when compared to old age-matched wild type ones
Manually annotated by BRENDA team
-
high glucose level of 25 mM leads to a decrease in G6PD activity and protein level in islets
Manually annotated by BRENDA team
-
extralesional and wild-type, the lesions show a 20fold higher, and extralesional parenchyma a 2fold higher, virtual flux at physiological substrate concentrations compared to normal parenchyma
Manually annotated by BRENDA team
-
murine thymic lymphoma cells
Manually annotated by BRENDA team
additional information