1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) This is an abbreviated version! For detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file .
Reaction
6-phospho-D-gluconate +
NADP+ =
D-ribulose 5-phosphate +
CO2 +
NADPH +
H+
Synonyms 6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase 1, 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, 6PGDH1, 6PGDH2, 6PGDH3, At1G64190, At3g02360, At5g41670, D-gluconate-6-phosphate dehydrogenase, GCG1, gnd, GND1, Gnd1p, Gnd2p, GNTZII, LlPDH, Moth_1283, Os6PGDH1, Os6PGDH2, p6PGDH, peroxisomal 6-phosphogluconate dehydrogenase, Pgd, PGD1, PGD2, PGD3, phosphogluconic acid dehydrogenase, TM0438, YpjI, zwf3
ECTree
Subunits
Subunits on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
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homodimer or heterodimer
-
-
?
x * 53577, calculated from amino acid sequence
?
-
x * 60000, spliced Gnd1-3xHA isoform, SDS-PAGE
?
-
x * 63000, alternatively spliced Gnd1-3xHA isoform, SDS-PAGE
?
-
x * 50000, His6-tagged enzyme, SDS-PAGE
?
-
x * 50000, His6-tagged enzyme, SDS-PAGE
-
?
x * 52400, calculated from sequence
dimer
-
1 * 49000 + 1 * 45000, SDS-PAGE
dimer
-
2 * 52000, SDS-PAGE
dimer
-
-
286824 , 286831 , 286833 , 286834 , 286836 , 286849 , 286851 , 286852 , 286860 , 286869 , 286875 , 286881 , 286882 , 286883 , 286890 , 286895 , 286902 , 286903
dimer
-
2 * 50000, type I, SDS-PAGE
dimer
Drosophila sp. (in: flies)
-
2 * 50000, SDS-PAGE
dimer
-
2 * 52000, SDS-PAGE
dimer
-
2 * 30000, SDS-PAGE
dimer
-
2 * 50000, SDS-PAGE
dimer
-
2 * 51000, SDS-PAGE
dimer
-
2 * 50000, SDS-PAGE
-
dimer
-
2 * 51000, SDS-PAGE
-
dimer
-
2 * 52000, SDS-PAGE
dimer
-
2 * 54000, maleic anhydride electrophoresis
dimer
-
2 * 57000, SDS-PAGE
dimer
-
heteromultimeric molecule composed of 2 nonidentical subunits
dimer
-
2 * 52000, SDS-PAGE
dimer
-
-
286827 , 286831 , 286838 , 286840 , 286849 , 286852 , 286881 , 286883 , 286890 , 286899 , 286903 , 286987
dimer
-
2 * 47000, SDS-PAGE
dimer
-
2 * 51000, SDS-PAGE
dimer
-
2 * 52000, SDS-PAGE
dimer
-
2 * 50000, SDS-PAGE
dimer
2 * 59000, SDS-PAGE
dimer
-
2 * 52000, SDS-PAGE
dimer
-
2 * 52000, SDS-PAGE
-
dimer
-
2 * 55000, SDS-PAGE
dimer
-
2 * 54000, cytosolic isoenzyme, SDS-PAGE
dimer
2 * 51980, sequence determination, 2 * 51400, recombinant enzyme, SDS-PAGE
dimer
-
2 * 58000, SDS-PAGE
homodimer
-
2 * 57000, SDS-PAGE
homodimer
x-ray crystallography
homodimer
-
2 * 57000, SDS-PAGE
homodimer
-
x-ray crystallography
homodimer
-
2 * 49000, SDS-PAGE
homodimer
monomers act independently to each other. Each monomer consists of large alpha-helical domain while small beta-alpha-beta domain, forming a six stranded beta-sheet
homodimer
x-ray crystallography
homodimer
-
x-ray crystallography
-
tetramer
-
4 * 57000, SDS-PAGE
tetramer
-
4 * 57000, SDS-PAGE
-
tetramer
-
4 * 38000, SDS-PAGE
additional information
three-dimensional structure homology modeling of wild-type 6PGDH from Moorella thermoacetica and mutants based on the structure of human enzyme 6PGDH, PDB ID 2JKV
additional information
three-dimensional structure modelling, low stability due to absence of inter-subunit salt bridges as compared to the enzyme from Trypanosoma brucei, the monomeric enzyme is inactive