1.1.1.431: D-xylose reductase (NADPH)
This is an abbreviated version!
For detailed information about D-xylose reductase (NADPH), go to the full flat file.
Reaction
Synonyms
ALR1, Cb-XR, CbXR, CtXR, D-xylose reductase, D-xylose reductase 1, D-xylose reductase 2, D-xylose reductase 3, DnXR, GRE3, monospecific xylose reductase, More, msXR, NAD(P)H-dependent D-xylose reductase, NAD(P)H-dependent xylose reductase, NADPH dependent D-xylose reductase, NADPH-dependent D-xylose reductase II,III, NADPH-dependent xylose reductase, NADPH-preferring xylose reductase, NRRL3_10868, SsXR, Texr, TrxR, XR1, XR2, XR3, XRTL, XYL1, xylose reductase, xyr8, XyrA, XyrB
ECTree
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Reference on EC 1.1.1.431 - D-xylose reductase (NADPH)
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mayerhoff, Z.D.; Roberto, I.C.; Franco, T.T.
Response surface methodology as an approach to determine the optimal activities of xylose reductase and xylitol dehydrogenase enzymes from Candida mogii
Appl. Microbiol. Biotechnol.
70
761-767
2006
[Candida] mogii
de Groot, M.J.; Prathumpai, W.; Visser, J.; Ruijter, G.J.
Metabolic control analysis of Aspergillus niger L-arabinose catabolism
Biotechnol. Prog.
21
1610-1616
2005
Aspergillus niger
Chen, L.C.; Huang, S.C.; Chuankhayan, P.; Chen, C.D.; Huang, Y.C.; Jeyakanthan, J.; Pang, H.F.; Men, L.C.; Chen, Y.C.; Wang, Y.K.; Liu, M.Y.; Wu, T.K.; Chen, C.J.
Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis
Acta Crystallogr. Sect. F
65
419-421
2009
Candida tropicalis (C1K8Y9)
Kratzer, R.; Leitgeb, S.; Wilson, D.K.; Nidetzky, B.
Probing the substrate binding site of Candida tenuis xylose reductase (AKR2B5) with site-directed mutagenesis
Biochem. J.
393
51-58
2006
Yamadazyma tenuis (O74237)
Rawat, U.B.; Rao, M.B.
Purification, kinetic characterization and involvement of tryptophan residue at the NADPH binding site of xylose reductase from Neurospora crassa
Biochim. Biophys. Acta
1293
222-230
1996
Neurospora crassa
Krahulec, S.; Klimacek, M.; Nidetzky, B.
Engineering of a matched pair of xylose reductase and xylitol dehydrogenase for xylose fermentation by Saccharomyces cerevisiae
Biotechnol. J.
4
684-694
2009
Yamadazyma tenuis
Wang, X.; Fang, B.; Luo, J.; Li, W.; Zhang, L.
Heterologous expression, purification, and characterization of xylose reductase from Candida shehatae
Biotechnol. Lett.
29
1409-1412
2007
Scheffersomyces shehatae (A0MTG4)
Branco, R.; dos Santos, J.; Sarrouh, B.; Rivaldi, J.; Pessoa Jr., A.; da Silva, S.
Profiles of xylose reductase, xylitol dehydrogenase and xylitol production under different oxygen transfer volumetric coefficient values
J. Chem. Technol. Biotechnol.
84
326-330
2009
Meyerozyma guilliermondii, Meyerozyma guilliermondii FTI 20037
-
de Faria, J.T.; Sampaio, F.C.; Converti, A.; Passos, F.M.; Minim, V.P.; Minim, L.A.
Use of response surface methodology to evaluate the extraction of Debaryomyces hansenii xylose reductase by aqueous two-phase system
J. Chromatogr. B
877
3031-3037
2009
Debaryomyces hansenii, Debaryomyces hansenii UFV-170 XR
Yokoyama, S.-I.; Suzuki, T.; Kawai, K.; Horitsu, H.; Takamizawa, K.
Purification, characterization and structure analysis of NADPH-dependent D-xylose reductases from Candida tropicalis
J. Ferment. Bioeng.
79
217-223
1995
Candida tropicalis, Candida tropicalis IF0 0618
-
Hasper, A.A.; Visser, J.; de Graaff, L.H.
The Aspergillus niger transcriptional activator XlnR, which is involved in the degradation of the polysaccharides xylan and cellulose, also regulates D-xylose reductase gene expression
Mol. Microbiol.
36
193-200
2000
Aspergillus niger (Q9P8R5), Aspergillus niger
Jeong, E.Y.; Sopher, C.; Kim, I.S.; Lee, H.
Mutational study of the role of tyrosine-49 in the Saccharomyces cerevisiae xylose reductase
Yeast
18
1081-1089
2001
Saccharomyces cerevisiae
Kim, S.; Yun, J.; Kim, S.; Seo, J.; Park, J.
Production of xylitol from D-xylose and glucose with recombinant Corynebacterium glutamicum
Enzyme Microb. Technol.
46
366-371
2010
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
-
Agrawal, M.; Chen, R.R.
Discovery and characterization of a xylose reductase from Zymomonas mobilis ZM4
Biotechnol. Lett.
33
2127-2133
2011
Zymomonas mobilis subsp. mobilis (F2YCN5)
Hong, Y.; Dashtban, M.; Kepka, G.; Chen, S.; Qin, W.
Overexpression of D-xylose reductase (xyl 1) gene and antisense inhibition of D-xylulokinase (xyiH) gene increase xylitol production in Trichoderma reesei
BioMed Res. Int.
2014
169705
2014
Trichoderma reesei (Q876L8), Trichoderma reesei
Weyda, I.; Luebeck, M.; Ahring, B.K.; Luebeck, P.S.
Point mutation of the xylose reductase (XR) gene reduces xylitol accumulation and increases citric acid production in Aspergillus carbonarius
J. Ind. Microbiol. Biotechnol.
41
733-739
2014
Aspergillus carbonarius, Aspergillus carbonarius ITEM 5010
Rafiqul, I.S.; Sakinah, A.M.
Biochemical properties of xylose reductase prepared from adapted strain of Candida tropicalis
Appl. Biochem. Biotechnol.
175
387-399
2015
Candida tropicalis
Paidimuddala, B.; Rathod, A.; Gummadi, S.
Inhibition of Debaryomyces nepalensis xylose reductase by lignocellulose derived by-products
Biochem. Eng. J.
121
73-82
2017
Debaryomyces nepalensis (A0A0M4HL56)
-
Rafiqul, I.S.; Sakinah, A.M.; Zularisam, A.W.
Inhibition by toxic compounds in the hemicellulosic hydrolysates on the activity of xylose reductase from Candida tropicalis
Biotechnol. Lett.
37
191-196
2015
Candida tropicalis, Candida tropicalis IFO 0618
Boontham, W.; Srisuk, N.; Kokaew, K.; Treeyoung, P.; Limtong, S.; Thamchaipenet, A.; Yurimoto, H.
Xylitol production by thermotolerant methylotrophic yeast Ogataea siamensis and its xylose reductase gene (XYL1) cloning
Chiang Mai J. Sci.
41
491-502
2014
Ogataea siamensis (C0LSY9), Ogataea siamensis N22 (C0LSY9)
-
Komeda, H.; Yamasaki-Yashiki, S.; Hoshino, K.; Asano, Y.
Identification and characterization of D-xylose reductase involved in pentose catabolism of the zygomycetous fungus Rhizomucor pusillus
J. Biosci. Bioeng.
119
57-64
2015
Rhizomucor pusillus (I7HD84), Rhizomucor pusillus, Rhizomucor pusillus NBRC 4578 (I7HD84), Rhizomucor pusillus NBRC 4578
Hirabayashi, S.; Wang, J.; Kawagishi, H.; Hirai, H.
Improving xylitol production through recombinant expression of xylose reductase in the white-rot fungus Phanerochaete sordida YK-624
J. Biosci. Bioeng.
120
6-8
2015
Phanerodontia chrysosporium
Khattab, S.M.; Saimura, M.; Kodaki, T.
Boost in bioethanol production using recombinant Saccharomyces cerevisiae with mutated strictly NADPH-dependent xylose reductase and NADP+-dependent xylitol dehydrogenase
J. Biotechnol.
165
153-156
2013
Scheffersomyces stipitis (P31867), Scheffersomyces stipitis
Sim, H.S.; Park, E.H.; Kwon, S.Y.; Choi, S.K.; Lee, S.H.; Kim, M.D.
Cloning of the xylose reductase gene of Candida milleri
J. Microbiol. Biotechnol.
23
984-992
2013
Kazachstania humilis (M9RYL7)
Jin, L.Q.; Xu, W.; Yang, B.; Liu, Z.Q.; Zheng, Y.G.
Efficient biosynthesis of xylitol from xylose by coexpression of xylose reductase and glucose dehydrogenase in Escherichia coli
Appl. Biochem. Biotechnol.
187
1143-1157
2019
Rhizopus arrhizus (W5RZ21)
Zhang, M.; Puri, A.K.; Wang, Z.; Singh, S.; Permaul, K.
A unique xylose reductase from Thermomyces lanuginosus effect of lignocellulosic substrates and inhibitors and applicability in lignocellulosic bioconversion
Biores. Technol.
281
374-381
2019
Thermomyces lanuginosus (A0A455KZK8), Thermomyces lanuginosus SSBP (A0A455KZK8)
Fan, E.S.; Lu, K.W.; Wen, R.C.; Shen, C.R.
Photosynthetic reduction of xylose to xylitol using cyanobacteria
Biotechnol. J.
15
e1900354
2020
[Candida] boidinii (Q8X195), [Candida] boidinii
Terebieniec, A.; Chroumpi, T.; Dilokpimol, A.; Aguilar-Pontes, M.V.; Maekelae, M.R.; de Vries, R.P.
Characterization of D-xylose reductase, XyrB, from Aspergillus niger
Biotechnol. Rep.
30
e00610
2021
Aspergillus niger
Hossain, A.S.; Teparic, R.; Mrsa, V.
Comparison of two models of surface display of xylose reductase in the Saccharomyces cerevisiae cell wall
Enzyme Microb. Technol.
123
8-14
2019
Saccharomyces cerevisiae (P38715), Saccharomyces cerevisiae ATCC 204508 (P38715)
Malla, S.; Gummadi, S.N.
Counteraction of osmolytes on pH-induced unfolding of xylose reductase from Debaryomyces nepalensis NCYC 3413
Eur. Biophys. J.
49
267-277
2020
Debaryomyces nepalensis (A0A0M4HL56), Debaryomyces nepalensis NCYC 3413 (A0A0M4HL56)
Paidimuddala, B.; Mohapatra, S.B.; Gummadi, S.N.; Manoj, N.
Crystal structure of yeast xylose reductase in complex with a novel NADP-DTT adduct provides insights into substrate recognition and catalysis
FEBS J.
285
4445-4464
2018
Debaryomyces nepalensis (A0A0M4HL56)
Chang, Z.; Liu, D.; Yang, Z.; Wu, J.; Zhuang, W.; Niu, H.; Ying, H.
Efficient xylitol production from cornstalk hydrolysate using engineered Escherichia coli whole cells
J. Agric. Food Chem.
66
13209-13216
2018
Yamadazyma tenuis (O74237), Candida tropicalis (P87039), Yamadazyma tenuis CBS 4435 (O74237), Candida tropicalis IFO 0618 (P87039)
Son, H.F.; Lee, S.M.; Kim, K.J.
Structural insight into D-xylose utilization by xylose reductase from Scheffersomyces stipitis
Sci. Rep.
8
17442
2018
Scheffersomyces stipitis (P31867), Scheffersomyces stipitis, Scheffersomyces stipitis ATCC 58785 (P31867), Scheffersomyces stipitis NBRC 10063 (P31867), Scheffersomyces stipitis NRRL Y-11545 (P31867)
Sene, L.; Felipe, M.; Silva, S.; Vitolo, M.
Preliminary kinetic characterization of xylose reductase and xylitol dehydrogenase extracted from Candida guilliermondii FTI 20037 cultivated in sugarcane bagasse hydrolysate for xylitol production
Appl. Biochem. Biotechnol.
91-93
671-680
2001
Meyerozyma guilliermondii
Schneider, H.; Lee, H.; Barbosa, M.d.e. .F.; Kubicek, C.P.; James, A.P.
Physiological properties of a mutant of Pachysolen tannophilus deficient in NADPH-dependent D-xylose reductase
Appl. Environ. Microbiol.
55
2877-2881
1989
Pachysolen tannophilus
Nidetzky, B.; Mayr, P.; Hadwiger, P.; Stuetz, A.
Binding energy and specificity in the catalytic mechanism of yeast aldose reductases
Biochem. J.
344
101-107
1999
[Candida] intermedia, Saitozyma flava
Pratter, S.M.; Eixelsberger, T.; Nidetzky, B.
Systematic strain construction and process development Xylitol production by Saccharomyces cerevisiae expressing Candida tenuis xylose reductase in wild-type or mutant form
Biores. Technol.
198
732-738
2015
Yamadazyma tenuis (O74237)
Bolen, P.L.; Detroy, R.W.
Induction of NADPH-linked D-xylose reductase and NAD-linked xylitol dehydrogenase activities in Pachysolen tannophilus by D-xylose, L-arabinose, or D-galactose
Biotechnol. Bioeng.
27
302-307
1985
Pachysolen tannophilus
Nidetzky, B.; Brueggler, K.; Kratzer, R.; Mayr, P.
Multiple forms of xylose reductase in Candida intermedia comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies
J. Agric. Food Chem.
51
7930-7935
2003
[Candida] intermedia
Mayr, P.; Brueggler, K.; Kulbe, K.D.; Nidetzky, B.
D-Xylose metabolism by Candida intermedia isolation and characterisation of two forms of aldose reductase with different coenzyme specificities
J. Chromatogr. B Biomed. Sci. Appl.
737
195-202
2000
[Candida] intermedia
Zhang, B.; Li, L.; Zhang, J.; Gao, X.; Wang, D.; Hong, J.
Improving ethanol and xylitol fermentation at elevated temperature through substitution of xylose reductase in Kluyveromyces marxianus
J. Ind. Microbiol. Biotechnol.
40
305-316
2013
Kluyveromyces marxianus, Kluyveromyces marxianus YHJ010
Xia, X.L.; Cong, S.; Weng, X.R.; Chen, J.H.; Wang, J.F.; Chou, K.C.
Molecular simulation to investigate the cofactor specificity for Pichia stipitis xylose reductase
Med. Chem.
9
985-992
2013
Scheffersomyces stipitis
Chroumpi, T.; Peng, M.; Aguilar-Pontes, M.; Mueller, A.; Wang, M.; Yan, J.; Lipzen, A.; Ng, V.; Grigoriev, I.; Maekelae, M.; de Vries, R.
Revisiting a 'simple' fungal metabolic pathway reveals redundancy, complexity and diversity
Microb. Biotechnol.
14
2525-2537
2021
Aspergillus niger
Petschacher, B.; Nidetzky, B.
Altering the coenzyme preference of xylose reductase to favor utilization of NADH enhances ethanol yield from xylose in a metabolically engineered strain of Saccharomyces cerevisiae
Microb. Cell Fact.
7
0000
2008
Yamadazyma tenuis
-
Krahulec, S.; Petschacher, B.; Wallner, M.; Longus, K.; Klimacek, M.; Nidetzky, B.
Fermentation of mixed glucose-xylose substrates by engineered strains of Saccharomyces cerevisiae role of the coenzyme specificity of xylose reductase, and effect of glucose on xylose utilization
Microb. Cell Fact.
9
16
2010
Yamadazyma tenuis
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