1.1.1.428: 4-methylthio 2-oxobutanoate reductase (NADH)

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For detailed information about 4-methylthio 2-oxobutanoate reductase (NADH), go to the full flat file.

Reaction

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate

Synonyms

4-methylthio 2-oxobutyrate reductase, 4-methylthio 2-oxobutyric acid reductase, C-terminal binding protein 1, C-terminal-binding protein 1, C-terminal-binding protein 2, CtBP, CTBP1, CtBP2, MTOB reductase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.428 4-methylthio 2-oxobutanoate reductase (NADH)

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Results	in table
2	AA Sequence
2	Cloned(Commentary)
6	Cofactor
4	Crystallization (Commentary)
18	IC50 Value
29	Inhibitors
11	kcat/KM [mM/s]
3	Natural Substrates/ Products (Substrates)
6	Organism
1	Protein Variants
2	Purification (Commentary)
1	Reaction
5	Reference
2	Source Tissue
15	Substrates and Products (Substrate)
1	Subunits
17	Synonyms
1	Systematic Name

Systematic Name

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Systematic Name on EC 1.1.1.428 - 4-methylthio 2-oxobutanoate reductase (NADH)

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(2R)-2-hydroxy-4-(methylsulfanyl)butanoate:NAD+ 2-oxidoreductase

The substrate of this enzyme is formed as an intermediate during L-methionine salvage from S-methyl-5'-thioadenosine, which is formed during the biosynthesis of polyamines. The human enzyme also functions as a transcriptional co-regulator that downregulates the expression of many tumor-suppressor genes, thus providing a link between gene repression and the methionine salvage pathway. A similar, but NADP-specific, enzyme is involved in dimethylsulfoniopropanoate biosynthesis in algae and phytoplankton.