1.1.1.428: 4-methylthio 2-oxobutanoate reductase (NADH)

This is an abbreviated version!
For detailed information about 4-methylthio 2-oxobutanoate reductase (NADH), go to the full flat file.

Reaction

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate

+

NAD⁺

=

4-(methylsulfanyl)-2-oxobutanoate

+

NADH

+

H+

Synonyms

4-methylthio 2-oxobutyrate reductase, 4-methylthio 2-oxobutyric acid reductase, C-terminal binding protein 1, C-terminal-binding protein 1, C-terminal-binding protein 2, CtBP, CTBP1, CtBP2, MTOB reductase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.428 4-methylthio 2-oxobutanoate reductase (NADH)

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Results	in table
2	AA Sequence
2	Cloned(Commentary)
6	Cofactor
4	Crystallization (Commentary)
18	IC50 Value
29	Inhibitors
11	kcat/KM [mM/s]
3	Natural Substrates/ Products (Substrates)
6	Organism
1	Protein Variants
2	Purification (Commentary)
1	Reaction
5	Reference
2	Source Tissue
15	Substrates and Products (Substrate)
1	Subunits
17	Synonyms
1	Systematic Name

Inhibitors

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Inhibitors on EC 1.1.1.428 - 4-methylthio 2-oxobutanoate reductase (NADH)

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(2Z)-2-(hydroxyimino)-3-phenylpropanoic acid

-

potent inhibitor

-

(2Z)-2-hydrazinylidene-3-phenylpropanoic acid

-

-

-

1-phenylpropan-2-one

-

-

2-(hydroxyimino)-3-(2-methoxyphenyl)propanoic acid

-

-

-

2-(hydroxyimino)-3-(3-hydroxyphenyl)propanoic acid

-

-

-

2-(hydroxyimino)-3-(3-methoxyphenyl)propanoic acid

-

-

-

2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid

-

-

-

2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid

-

-

-

2-(hydroxyimino)-3-m-tolylpropanoic acid

-

-

-

2-(hydroxyimino)-3-o-tolylpropanoic acid

-

-

-

2-(hydroxyimino)-3-p-tolylpropanoic acid

-

-

-

2-(hydroxyimino)-3-phenylpropanoic acid

show

-

2-benzylprop-2-enoic acid

-

-

-

2-hydrazono-3-phenylpropanoic acid

-

-

-

2-Oxopropanoic acid

-

-

3-(2-chlorophenyl)-2-(hydroxyimino)propanoic acid

-

-

-

3-(3-chlorophenyl)-2-(hydroxyimino)propanoic acid

-

-

-

3-(4-chlorophenyl)-2-(hydroxyimino)propanoic acid

-

-

-

3-(4-cyanophenyl)-2-(hydroxyimino)propanoic acid

-

-

-

3-(4-fluorophenyl)-2-(hydroxyimino)propanoic acid

-

-

-

3-phenyl-2-thioxopropanoic acid

-

-

-

3-Phenylpropanoic acid

-

-

4-(methylsulfanyl)-2-oxobutanoate

show

benzylpropanedioic acid

-

-

-

oxo(phenyl)acetic acid

-

-

oxo(phenylamino)acetic acid

-

-

phenylpyruvate

-

-

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Release 2023.1 (January 2023)