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1.1.1.428: 4-methylthio 2-oxobutanoate reductase (NADH)

This is an abbreviated version!
For detailed information about 4-methylthio 2-oxobutanoate reductase (NADH), go to the full flat file.

Reaction

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate
+
NAD+
=
4-(methylsulfanyl)-2-oxobutanoate
+
NADH
+
H+

Synonyms

4-methylthio 2-oxobutyrate reductase, 4-methylthio 2-oxobutyric acid reductase, C-terminal binding protein 1, C-terminal-binding protein 1, C-terminal-binding protein 2, CtBP, CTBP1, CtBP2, MTOB reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.428 4-methylthio 2-oxobutanoate reductase (NADH)

IC50 Value

IC50 Value on EC 1.1.1.428 - 4-methylthio 2-oxobutanoate reductase (NADH)

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0024
(2Z)-2-(hydroxyimino)-3-phenylpropanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.1
2-(hydroxyimino)-3-(2-methoxyphenyl)propanoic acid
Homo sapiens
-
IC50 above 0.1 mM, at pH 7.1 and 25°C
-
0.00072
2-(hydroxyimino)-3-(3-hydroxyphenyl)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00088
2-(hydroxyimino)-3-(3-methoxyphenyl)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00734
2-(hydroxyimino)-3-(4-hydroxyphenyl)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00216
2-(hydroxyimino)-3-(4-methoxyphenyl)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00048
2-(hydroxyimino)-3-m-tolylpropanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00873
2-(hydroxyimino)-3-o-tolylpropanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00032
2-(hydroxyimino)-3-p-tolylpropanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00024 - 0.000745
2-(hydroxyimino)-3-phenylpropanoic acid
-
0.00765
3-(2-chlorophenyl)-2-(hydroxyimino)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00017
3-(3-chlorophenyl)-2-(hydroxyimino)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.00018
3-(4-chlorophenyl)-2-(hydroxyimino)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.0009
3-(4-cyanophenyl)-2-(hydroxyimino)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
0.0003
3-(4-fluorophenyl)-2-(hydroxyimino)propanoic acid
Homo sapiens
-
at pH 7.1 and 25°C
-
300
4-(methylsulfanyl)-2-oxobutanoate
Homo sapiens
-
at pH 7.1 and 25°C
0.135
phenylpyruvate
Homo sapiens
-
pH and temperature not specified in the publication