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1.1.1.42: isocitrate dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about isocitrate dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.42

Reaction

isocitrate
+
NADP+
=
2-oxoglutarate
+
CO2
+
NADPH
+
H+

Synonyms

AbIDH1, AfIDH, CgIDH, cICDH, CtIDP1, CtIDP2, cytosolic isocitrate dehydrogenase 1, cytosolic NADP(+)-dependent isocitrate dehydrogenase, cytosolic NADP+-dependent isocitrate dehydrogenase, cytosolic NADP-dependent isocitrate dehydrogenase, cytosolic NADPH-dependent isocitrate dehydrogenase, DpIDH, EcIDH, HICDH, ICD, ICD1, ICD2, icdA, ICDH, ICDH-1, IDH, IDH-90, IDH-I, IDH-IIa, IDH-IIb, IDH1, IDH2, IDH3, IDHP, IDP, IDP1, IDP2, IDP3, IDPA, IDPc, IDPm, isocitrate dehydrogenase, isocitrate dehydrogenase (NADP), isocitrate dehydrogenase (NADP-dependent), isocitrate dehydrogenase (nicotinamide adenine dinucleotide phosphate), isocitrate dehydrogenase 1, isocitrate dehydrogenase 2, isocitrate dehydrogenase-1, isocytrate deyhdrogenase, mICDH, mitochondrial NADP+-dependent isocitrate dehydrogenase, NAD+-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, NADP+ dependent isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate dehydrogenase, NADP+-dependent Ds-threo-isocitrate:NADP+ oxidoreductase, NADP+-dependent ICDH, NADP+-dependent IDH, NADP+-dependent isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, NADP+-isocitrate dehydrogenase, NADP+-linked isocitrate dehydrogenase, NADP+-specific ICDH, NADP+-specific IDH, NADP+-specific isocitrate dehydrogenase, NADP-dependent IDH, NADP-dependent isocitrate dehydrogenase, NADP-dependent isocitric dehydrogenase, NADP-ICDH, NADP-IDH, NADP-IDH Idp1p, NADP-isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-specific isocitrate dehydrogenase, NADPH-dependent isocitrate dehydrogenase, NADPH-IDH, oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, perICDH, PS-NADP-IDH, TaIDH, TM1148, YlIDP

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.42 isocitrate dehydrogenase (NADP+)

Substrates Products

Substrates Products on EC 1.1.1.42 - isocitrate dehydrogenase (NADP+)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2R,3S)-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
show the reaction diagram
(2R,3S)-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
show the reaction diagram
2-oxoglutarate + CO2 + NADPH
isocitrate + NADP+
show the reaction diagram
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
show the reaction diagram
2-oxoglutarate + NADPH + H+
2-hydroxyglutarate + NADP+
show the reaction diagram
the reaction is catalyzed by mutant enzymes R153H and R153C
-
-
?
2-oxoglutarate + NADPH + H+
D-2-hydroxyglutarate + NADP+
show the reaction diagram
3-fluoroisocitrate + NADP+
3-fluoro-2-oxoglutarate + NADPH + CO2
show the reaction diagram
-
-
-
-
?
3-hydroxyisocitrate + NADP+
3-hydroxy-2-oxoglutarate + NADPH + CO2
show the reaction diagram
-
-
-
-
?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
show the reaction diagram
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
show the reaction diagram
-
-
-
?
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH
show the reaction diagram
DL-isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
show the reaction diagram
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
show the reaction diagram
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
show the reaction diagram
Ds-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
show the reaction diagram
-
-
-
-
?
isocitrate + APADP+
2-oxoglutarate + CO2 + APADPH
show the reaction diagram
isocitrate + NAD+
2-oxoglutarate + CO2 + NADH + H+
show the reaction diagram
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
show the reaction diagram
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
show the reaction diagram
isocitrate + NADP+
oxalosuccinate + NADPH + H+
show the reaction diagram
isocitrate + NHDP+
2-oxoglutarate + CO2 + NHDPH
show the reaction diagram
isopropylmalate + NADP+
?
show the reaction diagram
-
-
-
-
?
oxalosuccinate
2-oxoglutarate + CO2
show the reaction diagram
threo-Ds-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
show the reaction diagram
-
-
-
-
?
additional information
?
-