1.1.1.415: noscapine synthase

This is an abbreviated version!
For detailed information about noscapine synthase, go to the full flat file.

Reaction

Synonyms

NOS, SDR1, short-chain dehydrogenase/reductase

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.415 noscapine synthase

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1	AA Sequence
1	Application
2	Cloned(Commentary)
1	Cofactor
2	General Information
4	kcat/KM [mM/s]
4	KM Value [mM]
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
2	Organism
4	Pathway
1	Purification (Commentary)
1	Reaction
2	Reference
5	Source Tissue
6	Substrates and Products (Substrate)
4	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

Application

print visible entries

print all entries

Application on EC 1.1.1.415 - noscapine synthase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Application Search

synthesis

Papaver somniferum

I3PLR3

complete biosynthesis of noscapine and halogenated alkaloids in yeast and optimizing noscapine production toward scalable manufacturing. Engineered strain contains 25 heterologous plant, bacteria, and mammalian genes and 6 mutant or overexpressed yeast genes. The noscapine biosynthetic pathway incorporates seven endomembrane-localized plant enzymes, highlighting the ability of the yeast to functionally express and properly localize large numbers of heterologous enzymes into the endoplasm reticulum. Noscapine titers were improved by 18000fold (to low mg/l levels) via a combination of enzyme engineering, pathway and strain engineering, and fermentation optimization. Microbial fermentation can be used to produce halogenated alkaloid derivatives, which can ultimately serve as potential drug leads, through feeding amino acid derivatives to strains

749191