1.1.1.39: malate dehydrogenase (decarboxylating) This is an abbreviated version! For detailed information about malate dehydrogenase (decarboxylating), go to the full flat file .
Reaction
(S)-malate +
NAD+ =
pyruvate +
CO2 +
NADH +
H+
Synonyms AT2g13560, At4g00570, AZC3656 protein, cytosolic malic enzyme, decarboxylating NAD-malic enzyme, dehydrogenase, malate, diphosphate nucleotide dependent malic enzyme, DMA, DME, m-NAD-ME, malic enzyme, malic enzyme 2, malic enzyme-NAD, ME, ME-NAD, ME1, ME2, mitochondrial malic enzyme, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD+-dependent malic enzyme, mitochondrial NAD-malic enzyme, mNAD-ME1, mNAD-ME2, NAD(P)+-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent malate dehydrogenase (decarboxylating), NAD-dependent malic enzyme, NAD-dependent malic enzyme 1, NAD-dependent malic enzyme 2, NAD-malate dehydrogenase, NAD-malic enzyme, NAD-ME, NAD-ME1, NAD-ME2, NAD-MEH, NAD-preferring malic enzyme, NAD-preferring ME, NAD-specific malic enzyme, pyruvic-malic carboxylase
ECTree
KI Value
KI Value on EC 1.1.1.39 - malate dehydrogenase (decarboxylating)
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7.4
fructose 6-phosphate
pH 7.2, 30°C, versus (S)-malate
0.006
oxalate
-
pH 7.0, 25°C, recombinant wild-type enzyme
0.36
oxaloacetate
pH 7.2, 30°C, versus (S)-malate
additional information
additional information
-
0.45
5'-AMP
versus NAD+, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
1.5
5'-AMP
versus (S)-malate, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
3
CO2
versus NAD+, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
7
CO2
versus (S)-malate, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
58
L-aspartate
-
pH 8.4, 25°C, versus malate
80
L-aspartate
-
pH 7.0, 25°C, versus malate
0.0048
Lu3+
-
isomerized enzyme form, pH 7.4, 30°C
0.148
Lu3+
-
native enzyme form, pH 7.4, 30°C
0.041
NADH
versus (S)-malate, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
0.15
NADH
versus NAD+, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
11
pyruvate
versus NAD+, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
14
pyruvate
versus (S)-malate, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
0.8
Tartrate
versus (S)-malate, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
4
Tartrate
versus NAD+, pH 6.5, temperature not specified in the publication, isozyme NAD-ME2
additional information
additional information
-
-
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition kinetics
-
additional information
additional information
-
inhibition patterns by measuring the initial rate as a function of malate or NAD+ with NAD+ or malate maintained equal to its Km at different fixed concentrations of oxalate, including zero, Ki, 2Ki, and 4Ki at pH 7.0 and 30 mM free Mg2+
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