1.1.1.384: dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase

This is an abbreviated version, for detailed information about dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase, go to the full flat file.

Reaction

dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose
+
NADP+
=
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose
+
NADPH
+
H+

Synonyms

DTDP-3,4-diketo-2,6-dideoxyglucose 3-ketoreductase, dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose 3-oxidoreductase, dTDP-4-keto-2,6-dideoxy-D-glucose 3-oxidoreductase, jadP, KijD10, NDP-hexose 3-ketoreductase, OleW, SpnN

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.384 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase

Engineering

Engineering on EC 1.1.1.384 - dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase

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ENGINEERING
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
K102A
mutant protein is completely inactive
K102E
mutant enzyme retains some activity, but its catalytic efficiency is reduced by more than 4 orders of magnitude from that for the wild-type enzyme
K102M
mutant protein is completely inactive
K102Q
mutant protein is completely inactive