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1.1.1.381: 3-hydroxy acid dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxy acid dehydrogenase, go to the full flat file.

Reaction

L-2-amino-3-oxobutanoate
=
aminoacetone
+
CO2

Synonyms

ydfG, YMR226c

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.381 3-hydroxy acid dehydrogenase

Systematic Name

Systematic Name on EC 1.1.1.381 - 3-hydroxy acid dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
L-allo-threonine:NADP+ 3-oxidoreductase
The enzyme, purified from the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, shows activity with a range of 3- and 4-carbon 3-hydroxy acids. The highest activity is seen with L-allo-threonine and D-threonine. The enzyme from Escherichia coli also shows high activity with L-serine, D-serine, (S)-3-hydroxy-2-methylpropanoate and (R)-3-hydroxy-2-methylpropanoate. The enzyme has no activity with NAD+ or L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase).