1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating)

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For detailed information about malate dehydrogenase (oxaloacetate-decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.38

Reaction

(S)-malate
+
NAD+
=
pyruvate
+
CO2
+
NADH

Synonyms

m-NAD(P)-ME, malic enzyme, ME2, MHD, mitochondrial malic enzyme ME2, mitochondrial NAD(P) malic enzyme, mitochondrial NAD(P) malic enzyme ME2, mitochondrial NAD(P)+-dependent malic enzyme, mitochondrial NAD-malic enzyme, NAD+-dependent malic enzyme, NAD-dependent ME, NAD-malic enzyme, NAD-ME, NAD-specific malic enzyme, pyruvic-malic carboxylase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.38 malate dehydrogenase (oxaloacetate-decarboxylating)

General Information

General Information on EC 1.1.1.38 - malate dehydrogenase (oxaloacetate-decarboxylating)

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
knockdown of ME2 does not inhibit insulin release stimulated by glucose, pyruvate or 2-aminobicyclo [2,2,1]heptane-2-carboxylic acid-plus-glutamine
additional information
-
the molecular basis for the different allosteric properties and quaternary structural stability of m-NAD(P)-ME, EC 1.1.1.38 and c-NADP-ME, EC 1.1.1.40. The structural features near the fumarate binding site and the dimer interface are highly related to the quaternary structural stability of c-NADP-ME and m-NAD(P)-ME. Lys57 plays functional roles in both the allosteric regulation and the subunit-subunit interaction of humanm-NAD(P)-ME