1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about L-rhamnose 1-dehydrogenase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
AvLRA1, AvRhaDH, EAT09360, L-rhamnose 1-dehydrogenase, LRA1, NAD(P)+-dependent L-rhamnose-1-dehydrogenase, RhaDH, SpLRA1
ECTree
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Subunits
Subunits on EC 1.1.1.378 - L-rhamnose 1-dehydrogenase [NAD(P)+]
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additional information
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the subunit of AvRhaDH was a single-domain protein with an alpha/beta doubly wound structure. A seven-stranded parallel beta-sheet (beta3-beta2-beta1-beta4-beta5-beta6-beta7) in the center of the molecule is sandwiched by two arrays of parallel alpha-helices (alpha1 to alpha6), which is a typical dinucleotide binding the Rossmann fold motif including the characteristic sequence Gly-X3-Gly-X-Gly; Gly12-Ala13-Ser14-Arg15-Gly16-Ile17-Gly18. Furthermore, a motif corresponding to Asn92-Asn93-Ala94-Gly95 is previously shown to be important for stabilizing this central beta-sheet in other SDR superfamily enzymes. A small domain containing the alpha7 and two 310 helixes is slightly separated from the main body of the subunit, and contained the flexible region