1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.375

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD(P)+
=
a 2-oxocarboxylate
+
NAD(P)H
+
H+

Synonyms

MdhII, lactate/malate dehydrogenase, MJ0490, MJ0409, LDH-like L-MalDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

Substrates Products

Substrates Products on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(2S)-3-sulfolactate + NADP+
3-sulfopyruvate + NADPH + H+
show the reaction diagram
weak activity, Vmax/KM: 1/min*mg. The enzyme does not catalyse the oxidation of (2S)-3-sulfolactate with NAD+ as cofactor
-
-
r
(S)-malate + NAD+
oxaloacetate + NADH + H+
show the reaction diagram
(S)-malate + NADP+
oxaloacetate + NADPH + H+
show the reaction diagram
3-sulfopyruvate + NADH
(2R)-3-sulfolactate + NAD+
show the reaction diagram
3-sulfopyruvate + NADH + H+
(2S)-3-sulfolactate + NAD+
show the reaction diagram
Vmax/KM: 34/min*mg. The enzyme prefers oxaloacetate over 3-sulfopyruvate using NADH as cofactor
-
-
ir
3-sulfopyruvate + NADPH
(2R)-3-sulfolactate + NADP+
show the reaction diagram
the reverse oxidation reaction occurs at least ten to 20 times more slowly. Preference of NADPH over NADH
-
-
?
3-sulfopyruvate + NADPH + H+
(2S)-3-sulfolactate + NADP+
show the reaction diagram
oxaloacetate + NADH
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADH + H+
(S)-malate + NAD+
show the reaction diagram
oxaloacetate + NADPH
(S)-malate + NADP+
show the reaction diagram
oxaloacetate + NADPH + H+
(S)-malate + NADP+
show the reaction diagram
pyruvate + NADH
(S)-lactate + NAD+
show the reaction diagram
preference of NADPH over NADH. Activity is detected only when the allosteric activator fructose-1,6-bisphosphate is added to the assay mixture
-
-
?
pyruvate + NADH + H+
(S)-lactate + NAD+
show the reaction diagram
pyruvate + NADPH
(S)-lactate + NADP+
show the reaction diagram
preference of NADPH over NADH. Activity is detected only when the allosteric activator fructose-1,6-bisphosphate is added to the assay mixture
-
-
?
pyruvate + NADPH + H+
(S)-lactate + NADP+
show the reaction diagram
additional information
?
-