1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.375

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD(P)+
=
a 2-oxocarboxylate
+
NAD(P)H
+
H+

Synonyms

MdhII, lactate/malate dehydrogenase, MJ0490, MJ0409, LDH-like L-MalDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

Metals Ions

Metals Ions on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
in the presence of NADPH, 10 mM MgCl2, MnCl2 or CaCl2 is required to support full activity. When using NADH as coenzyme enzymatic activity is insensitive to salt concentration
K+
in the presence of NADPH, full enzymatic activity requires a minimum salt concentration of 0.1 M NaCl or KCl. At lower salt concentrations, the activity decreases by a factor of three. When using NADH as coenzyme enzymatic activity is insensitive to salt concentration
Mg2+
in the presence of NADPH, 10 mM MgCl2, MnCl2 or CaCl2 is required to support full activity. When using NADH as coenzyme enzymatic activity is insensitive to salt concentration
Mn2+
in the presence of NADPH, 10 mM MgCl2, MnCl2 or CaCl2 is required to support full activity. When using NADH as coenzyme enzymatic activity is insensitive to salt concentration
Na+
in the presence of NADPH, full enzymatic activity requires a minimum salt concentration of 0.1 M NaCl or KCl. At lower salt concentrations, the activity decreases by a factor of three. When using NADH as coenzyme enzymatic activity is insensitive to salt concentration