1.1.1.375: L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about L-2-hydroxycarboxylate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.375

Reaction

a (2S)-2-hydroxycarboxylate
+
NAD(P)+
=
a 2-oxocarboxylate
+
NAD(P)H
+
H+

Synonyms

MdhII, lactate/malate dehydrogenase, MJ0490, MJ0409, LDH-like L-MalDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.375 L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

KM Value

KM Value on EC 1.1.1.375 - L-2-hydroxycarboxylate dehydrogenase [NAD(P)+]

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
4.6
(2S)-3-sulfolactate
70°C, pH 9.5, cofactor: NADP+
0.025 - 0.15
(S)-malate
0.19 - 1.3
3-sulfopyruvate
0.14
NADH
70°C, pH 8.0
0.02 - 0.2
NADPH
0.06 - 0.3
oxaloacetate
0.84
pyruvate