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1.1.1.370: scyllo-inositol 2-dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about scyllo-inositol 2-dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.370

Reaction

scyllo-Inositol
+
NAD+
=
2,4,6/3,5-pentahydroxycyclohexanone
 +
NADH
 +
H+

Synonyms

DegA, IgdA, IolX, LgdA, NAD+-dependent SI dehydrogenase, Pl-scyllo-IDH, scyllo-inositol dehydrogenase, yisS

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.370 scyllo-inositol 2-dehydrogenase (NAD+)

Engineering

Engineering on EC 1.1.1.370 - scyllo-inositol 2-dehydrogenase (NAD+)

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D191A
site-directed mutagenesis
H195A
site-directed mutagenesis
H318A
site-directed mutagenesis, the kcat value for scyllo-inositol decreases resulting in a very weak activity compared to wild-type enzyme
K106A
site-directed mutagenesis
R178A
site-directed mutagenesis, the mutation increases the Km value by 10fold compared to wild-type and decreases the kcat value for scyllo-inositol as a substrate, the mutant shows reduced activity
additional information