1.1.1.368: 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

This is an abbreviated version!
For detailed information about 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase, go to the full flat file.

Reaction

6-hydroxycyclohex-1-ene-1-carbonyl-CoA
+
NAD+
=
6-oxocyclohex-1-ene-1-carbonyl-CoA
+
NADH
+
H+

Synonyms

HAD, ThaADH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.368 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

General Information

General Information on EC 1.1.1.368 - 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme belongs to the zinc-dependent alcohol dehydrogenases (ADHs)
metabolism
-
the enzyme is involved in the benzoate degradation pathway
additional information
-
ThaADH three-dimensional structure modeling overview. A bulky aromatic residue, that plays a crucial role in the definition of the substrate binding pockets of most ADHs, is replaced by a glycine residue in ThaADH. This structural difference leads to the formation of one large binding pocket instead of two smaller ones and consequently to a preference for cyclic diketones over linear bulky substrates