1.1.1.365: D-galacturonate reductase

This is an abbreviated version!
For detailed information about D-galacturonate reductase, go to the full flat file.

Reaction

Synonyms

AKR2, AnGaaA, AnGar1, Cd-GAR, D-galacturonate reductase, D-galacturonic acid reductase, D-galacturonic acid reductases, FaGalUR, gaaA, GalA reductase, galacturonate reductase, GalUR, gar1, GAR2, NADPH-dependent D-galacturonate reductase, PcGOR

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.365 D-galacturonate reductase

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Results	in table
2	Activating Compound
38	AA Sequence
3	Application
18	Cloned(Commentary)
29	Cofactor
4	Expression
21	General Information
7	Inhibitors
7	kcat/KM [mM/s]
18	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
77	Organism
10	Pathway
6	pH Optimum
1	pH Range
15	Protein Variants
3	Purification (Commentary)
1	Reaction
32	Reference
19	Source Tissue
8	Specific Activity [micromol/min/mg]
69	Substrates and Products (Substrate)
12	Subunits
67	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
11	Turnover Number [1/s]

Application

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Application on EC 1.1.1.365 - D-galacturonate reductase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

nutrition

Fragaria x ananassa

O49133

accumulation of high levels of ascorbate using GalUR gene overepression in tomato fruits. Tomato fruits are considered a major dietary source of vitamin C in many countries, because it is consumed regularly and in large quantities. Tomato also serves as a fruit model for other crops species with fleshy berry. Accordingly, it is very important to monitor and to increase the vitamin C content in tomato fruit, for meeting the consumer demand and health requirements for high nutrition, e.g. by overexpressing D-galacturonate reductase

743465

synthesis

2 entries

synthesis

Aspergillus niger

A2R7U3, A8DRH9

L-galactonate shows potential applications as an additive to nutrients and cosmetics. AnGar1 variants are developed that represent the a GalA reductases with a higher preference for NADH compared to NADPH. The altered cofactor-specificity enables the coupling of GalA reduction to glycolysis, resulting in higher yields of GalOA when glucose is used as a redox donor. The engineered AnGar1 should prove valuable for D-galacturonic acid utilization in pectin-rich hydrolysates, which contain neutral sugars such as glucose, galactose, or arabinose, all of which are funneled into glycolysis. The NADH-dependent GalA reductases can facilitate the coupling of L-galactonate production to the oxidation of glycerol, an abundant waste product that can be supplemented to pectin-rich hydrolysates

763698

synthesis

Aspergillus niger CBS 513.88

-

L-galactonate shows potential applications as an additive to nutrients and cosmetics. AnGar1 variants are developed that represent the a GalA reductases with a higher preference for NADH compared to NADPH. The altered cofactor-specificity enables the coupling of GalA reduction to glycolysis, resulting in higher yields of GalOA when glucose is used as a redox donor. The engineered AnGar1 should prove valuable for D-galacturonic acid utilization in pectin-rich hydrolysates, which contain neutral sugars such as glucose, galactose, or arabinose, all of which are funneled into glycolysis. The NADH-dependent GalA reductases can facilitate the coupling of L-galactonate production to the oxidation of glycerol, an abundant waste product that can be supplemented to pectin-rich hydrolysates

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