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1.1.1.359: aldose 1-dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about aldose 1-dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

an aldopyranose
+
NAD(P)+
=
an aldono-1,5-lactone
 +
NAD(P)H
 +
H+

Synonyms

gdh-1, glucose dehydrogenase, SsGDH, SSO3003

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]

Inhibitors

Inhibitors on EC 1.1.1.359 - aldose 1-dehydrogenase [NAD(P)+]

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
1 mM, pH 9, 22°C, rapid inactivation
5,5'-dithiobis-(2-nitrobenzoic acid)
1 mM, 50% inactivation
acetone
40% (v/v), 40% activity
ethanol
40% (v/v), 30% activity
methanol
40% (v/v), 50% activity
NADPH
inhibits the NAD+-dependentcarbohydrate oxidations in a competitive manner with respect to NAD+
NEM
3 mM, 2 h, 50% inactivation
Urea
40% (v/v), 85% activity
additional information
galactose (0.04 mM), mannose (0.04 mM) and ribose (0.04 mM) do not inhibit glucose oxidation by NAD+
-