1.1.1.359: aldose 1-dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about aldose 1-dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

an aldopyranose
+
NAD(P)+
=
an aldono-1,5-lactone
+
NAD(P)H
+
H+

Synonyms

gdh-1, glucose dehydrogenase, SsGDH, SSO3003

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.359 aldose 1-dehydrogenase [NAD(P)+]

Crystallization

Crystallization on EC 1.1.1.359 - aldose 1-dehydrogenase [NAD(P)+]

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
hanging drop, vapor-diffusion method, crystal structure of the apo form of glucose dehydrogenase to a resolution of 1.8 A and a complex with its required cofactor, NADP+, to a resolution of 2.3 A. Complexes of the enzyme with D-glucose and D-xylose are presented to resolutions of 1.6 and 1.5 A. A T41A mutation is engineered to enable the trapping of substrate in the crystal
the best crystals to date diffract to 1.8 A on a synchrotron source, have orthorhombic symmetry and belong to space group P2(1)2(1)2