1.1.1.358: 2-dehydropantolactone reductase

This is an abbreviated version!
For detailed information about 2-dehydropantolactone reductase, go to the full flat file.

Word Map on EC 1.1.1.358

Reaction

(R)-pantolactone
+
NADP+
=
2-dehydropantolactone
+
NADPH
+
H+

Synonyms

conjugated polyketone reductase, conjugated polyketone reductase C2, CPR-C1, CPR-C2, ketopantoyl-lactone reductase, NADPH-dependent ketopantoyl lactone reductase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.358 2-dehydropantolactone reductase

Inhibitors

Inhibitors on EC 1.1.1.358 - 2-dehydropantolactone reductase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-dehydropantolactone
-
competitive versus isatin
3,4-Dihydroxy-3-cyclobutene-1,2-dione
-
uncompetitive
Al3+
-
83%% inhibition, reduction of 2-dehydropantolactone
Cd2+
-
97% inhibition, reduction of 2-dehydropantolactone
Cu2+
-
completely inhibits reduction of 2-dehydropantolactone
cyclohexenediol-1,2,3,4-tetraone
-
uncompetitive
Hg2+
-
completely inhibits reduction of 2-dehydropantolactone
iodoacetate
-
1 mM, 49% inhibition
p-chloromercuribenzoate
-
0.1 mM, 72% inhibition
parabanic acid
-
uncompetitive
quercetin
-
0.1 mM, 94% inhibition
Zn2+
-
completely inhibits reduction of 2-dehydropantolactone