1.1.1.356: GDP-L-colitose synthase
This is an abbreviated version!
For detailed information about GDP-L-colitose synthase, go to the full flat file.
Reaction
Synonyms
ColC
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.356 - GDP-L-colitose synthase
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REACTION DIAGRAM
GDP-beta-L-colitose + NAD(P)+
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the enzyme is involved in GDP-L-fucose biosynthesis. L-Colitose is a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides
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-
?
GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NAD(P)H + H+
GDP-beta-L-colitose + NAD(P)+
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the enzyme is involved in GDP-L-fucose biosynthesis. L-Colitose is a 3,6-dideoxyhexose found in the O-antigen of Gram-negative lipopolysaccharides
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-
?
GDP-beta-L-colitose + NAD+
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bifunctional enzyme catalyzing the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose
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-
?
GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADH + H+
GDP-beta-L-colitose + NAD+
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bifunctional enzyme catalyzing the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose
-
-
?
GDP-beta-L-colitose + NADP+
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the enzyme catalyzes the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose. The stereochemical preference of ColC with regard to the transfer of one of the diastereotopic methylene hydrogens at C-4 of the dihydronicotinamide ring is established to be pro-S stereospecific
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-
?
GDP-4-dehydro-3,6-dideoxy-alpha-D-mannose + NADPH + H+
GDP-beta-L-colitose + NADP+
-
the enzyme catalyzes the C-5 epimerization of GDP-4-dehydro-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the resulting L-epimer to give GDP-L-colitose. The stereochemical preference of ColC with regard to the transfer of one of the diastereotopic methylene hydrogens at C-4 of the dihydronicotinamide ring is established to be pro-S stereospecific
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-
?