1.1.1.335: UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase

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For detailed information about UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.335

1.1.1.335

retroviral

capsid

retroviruses

trim5alpha

rhesus

tripartite

cyclophilin

antiretroviral

simian

macaque

trimcyps

anti-hiv-1

trim5-cyclophilin

indian-origin

post-entry

sivmac239

trim22

spry

alpha-mediated

synthesis

Reaction

UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate

UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate

Synonyms

PGN_0168, WblA, WbpB, WlbA

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.335 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase

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Results	in table
1	Activating Compound
123	AA Sequence
2	Application
7	Cloned(Commentary)
5	Cofactor
4	Crystallization (Commentary)
5	General Information
6	kcat/KM [mM/s]
8	KM Value [mM]
1	Molecular Weight [Da]
2	Natural Substrates/ Products (Substrates)
8	Organism
4	Pathway
1	pH Optimum
2	Protein Variants
1	Reaction
8	Reference
2	Storage Stability
10	Substrates and Products (Substrate)
1	Subunits
10	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
6	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 1.1.1.335 - UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase

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UDP-N-acetyl-2-amino-2-deoxy-alpha-D-glucuronate:NAD+ 3-oxidoreductase

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide. The enzymes from Pseudomonas aeruginosa serotype O5 and Thermus thermophilus form a complex with the the enzyme catalysing the next step the pathway (EC 2.6.1.98, UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase). The enzyme also possesses an EC 1.1.99.2 (L-2-hydroxyglutarate dehydrogenase) activity, and utilizes the 2-oxoglutarate produced by EC 2.6.1.98 to regenerate the tightly bound NAD+. The enzymes from Bordetella pertussis and Chromobacterium violaceum do not bind NAD+ as tightly and do not require 2-oxoglutarate to function.