1.1.1.328: nicotine blue oxidoreductase

This is an abbreviated version, for detailed information about nicotine blue oxidoreductase, go to the full flat file.

Reaction

3,3'-bipyridine-2,2',5,5',6,6'-hexol
+
NAD(P)+
=
(E)-2,2',5,5'-tetrahydroxy-6H,6'H-[3,3'-bipyridinylidene]-6,6'-dione
+
NAD(P)H
+
H+

Synonyms

NAD(P)H-nicotine blue oxidoreductase, NAD(P)H-nicotine blue quinone oxidoreductase, nboR

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.328 nicotine blue oxidoreductase

Systematic Name

Systematic Name on EC 1.1.1.328 - nicotine blue oxidoreductase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SYSTEMATIC NAME
IUBMB Comments
3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP+ 11-oxidoreductase
The enzyme, characterized from the nicotine degrading bacterium Arthrobacter nicotinovorans, catalyses the reduction of "nicotine blue" to its hydroquinone form (the opposite direction from that shown). Nicotine blue is the name given to the compound formed by the autocatalytic condensation of two molecules of 2,3,6-trihydroxypyridine, an intermediate in the nicotine degradation pathway. The main role of the enzyme may be to prevent the intracellular formation of nicotine blue semiquinone radicals, which by redox cycling would lead to the formation of toxic reactive oxygen species. The enzyme possesses a slight preference for NADH over NADPH.