1.1.1.324: 8-hydroxygeraniol dehydrogenase

This is an abbreviated version!
For detailed information about 8-hydroxygeraniol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.324

Reaction

(6E)-8-hydroxygeranial
+
NADP+
=
(6E)-8-oxogeranial
+
NADPH
+
H+

Synonyms

8-hydroxygeraniol oxidoreductase, acyclic monoterpene primary alcohol:NADP+ oxidoreductase, CrG10H, CYP76B10, G10H, SmG10H

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.324 8-hydroxygeraniol dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.324 - 8-hydroxygeraniol dehydrogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(6E)-8-hydroxygeraniol + 2 NADP+
(6E)-8-oxogeranial + 2 NADPH + 2 H+
show the reaction diagram
(6E)-8-hydroxynerol + 2 NADP+
? + 2 NADPH + 2 H+
show the reaction diagram
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additional information
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various branched-chain allylic primary alcohols, such as nerol, geraniol, and 8-hydroxygeraniol, are substrates, but ethanol is inert. The enzyme is also active with farnesol, 3-methyl-2-buten1-ol, citronellol, 4-isopropylbenzyl alcohol, trans-2-heptenol, and trans-2-hexenol. The enzyme exclusively transfers the pro-R hydrogen of NADPH to neral. No activity with linalool, 2,6-dimethyl-octane, iridodial, 1-octanol, 1-heptanol, 1-pentanol, 3-methyl-3-buten-1-ol, trans-crotyl alcohol, isopulegol, and menthol
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