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1.1.1.31: 3-hydroxyisobutyrate dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.31

Reaction

3-hydroxy-2-methylpropanoate
+
NAD+
=
2-Methyl-3-oxopropanoate
+
NADH
+
H+

Synonyms

3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3-hydroxyisobutyric acid dehydrogenase, 3HIBDH-IV, 3HIBDHI, At4g20930, AtHDH1, beta-hydroxyisobutyrate dehydrogenase, HDH1, HIBADH, HIBDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.31 3-hydroxyisobutyrate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(R)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
show the reaction diagram
(R)-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
(S)-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
show the reaction diagram
(S)-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
show the reaction diagram
100% activity
-
-
?
(S)-3-hydroxyisobutyrate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
show the reaction diagram
-
-
-
?
(S)-beta-hydroxyisobutyrate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
show the reaction diagram
-
-
-
-
r
(S)-methyl-3-hydroxy-2-methylpropionate + NAD+
?
show the reaction diagram
1.2% activity compared to (S)-3-hydroxyisobutyrate
-
-
?
2-methyl-D,L-serine + NAD+
?
show the reaction diagram
3-hydroxy-2-methylpropanoate + NAD+
2-methyl-3-oxopropanoate + NADH + H+
show the reaction diagram
3-hydroxy-2-methylpropanoate + NADP+
2-methyl-3-oxopropanoate + NADPH + H+
show the reaction diagram
3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
3-hydroxyisobutyric acid + NAD+
methylmalonic semialdehyde + NADH
show the reaction diagram
-
-
-
-
r
3-hydroxypropanoate + NAD(P)+
?
show the reaction diagram
3-hydroxypropanoate + NAD+
?
show the reaction diagram
3-hydroxypropanoate + NAD+
malonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
3-hydroxypropanoate + NADP+
malonate semialdehyde + NADPH + H+
show the reaction diagram
-
-
-
-
r
3-hydroxypropanoic acid + NAD+
3-oxopropanoate + NADH + H+
show the reaction diagram
substrate with much less efficiency compared to (S)-3-hydroxyisobutyrate
-
-
?
3-hydroxypropionate + NAD+
3-oxopropanoate + NADH + H+
show the reaction diagram
-
-
-
-
?
3-hydroxypropionate + NAD+
malonate semialdehyde + NADH + H+
show the reaction diagram
13% activity compared to (S)-3-hydroxyisobutyrate
-
-
?
3-hydroxypropionic acid + NAD+
malonate semialdehyde + NADH + H+
show the reaction diagram
D,L-3-hydroxyisobutyrate + NAD+
2-methyl-3-oxopropionate + NADH
show the reaction diagram
-
-
-
-
?
D,L-3-hydroxyisobutyrate + NAD+
D-2-methyl-3-oxopropionate + NADH
show the reaction diagram
D,L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
show the reaction diagram
D-3-hydroxyisobutyrate + NAD+
(S)-methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
D-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
DL-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
L-3-hydroxyisobutyrate + NAD+
(S)-methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
L-3-hydroxyisobutyrate + NAD+
3-oxoisobutyrate + NADH
show the reaction diagram
L-3-hydroxyisobutyrate + NAD+
L-2-methyl-3-oxopropionate + NADH
show the reaction diagram
L-3-hydroxyisobutyrate + NAD+
methylmalonate semialdehyde + NADH + H+
show the reaction diagram
-
-
-
-
r
L-serine + NAD+
3-oxo-L-alanine + NADH + H+
show the reaction diagram
L-serine + NAD+
?
show the reaction diagram
methyl (2S)-3-hydroxy-2-methylpropanoate + NAD+
methyl (2S)-2-methyl-3-oxopropanoate + NADH + H+
show the reaction diagram
methyl DL-serine + NAD+
methyl 3-oxo-DL-alanine + NADH + H+
show the reaction diagram
additional information
?
-