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1.1.1.31: 3-hydroxyisobutyrate dehydrogenase

This is an abbreviated version!
For detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.31

Reaction

3-hydroxy-2-methylpropanoate
+
NAD+
=
2-Methyl-3-oxopropanoate
+
NADH
+
H+

Synonyms

3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3-hydroxyisobutyric acid dehydrogenase, 3HIBDH-IV, 3HIBDHI, At4g20930, AtHDH1, beta-hydroxyisobutyrate dehydrogenase, HDH1, HIBADH, HIBDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.31 3-hydroxyisobutyrate dehydrogenase

General Information

General Information on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
3-hydroxyisobutyrate dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ acceptors
malfunction
At4g20930 knockdown plants show increased root growth inhibition of the mutants if cultivated in the presence of Val or Ile but not in the presence of leucine
metabolism
the enzyme is involved in both, valine and isoleucine degradation in Arabidopsis thaliana
physiological function
additional information
-
enzyme activity of HIBADH in spermatozoa from patients with asthenozoospermia is reduced compared to controls