1.1.1.31: 3-hydroxyisobutyrate dehydrogenase
This is an abbreviated version!
For detailed information about 3-hydroxyisobutyrate dehydrogenase, go to the full flat file.
Reaction
Synonyms
3-HIBADH, 3-hydroxyisobutyrate dehydrogenase, 3-hydroxyisobutyrate dehydrogenase-I, 3-hydroxyisobutyric acid dehydrogenase, 3HIBDH-IV, 3HIBDHI, At4g20930, AtHDH1, beta-hydroxyisobutyrate dehydrogenase, HDH1, HIBADH, HIBDH
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General Information
General Information on EC 1.1.1.31 - 3-hydroxyisobutyrate dehydrogenase
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evolution
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3-hydroxyisobutyrate dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ acceptors
malfunction
At4g20930 knockdown plants show increased root growth inhibition of the mutants if cultivated in the presence of Val or Ile but not in the presence of leucine
metabolism
the enzyme is involved in both, valine and isoleucine degradation in Arabidopsis thaliana
physiological function
additional information
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enzyme activity of HIBADH in spermatozoa from patients with asthenozoospermia is reduced compared to controls
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3-hydroxyisobutyrate dehydrogenase is a key enzyme for the metabolism of valine and some keto-bodies. It can catalyze reversible conversion of 3-hydroxyisobutyrate to methylmalonate semialdehyde
physiological function
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3-hydroxyisobutyrate dehydrogenase is one of the critical enzymes generating glucose by metabolizing amino acids in the gluconeogenesis pathway. It participates in valine, leucine, and isoleucine degradation and is a central metabolic enzyme in the valine catabolic pathway. The enzyme plays an important role in regulating sperm motility and may serve as a novel sperm-motility marker
physiological function
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the enzyme plays a role in the assembly of motile polar flagellum and in biofilm biomass accumulation
physiological function
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3-hydroxyisobutyrate dehydrogenase is a key enzyme for the metabolism of valine and some keto-bodies. It can catalyze reversible conversion of 3-hydroxyisobutyrate to methylmalonate semialdehyde
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physiological function
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the enzyme plays a role in the assembly of motile polar flagellum and in biofilm biomass accumulation
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