1.1.1.307: D-xylose reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about D-xylose reductase [NAD(P)H], go to the full flat file.

Reaction

Synonyms

AKR2B5, ALR2, CTHT_0056950, CtXR, dsXR, dual specific xylose reductase, KmXYL1, NAD(P)H-dependent D-xylose reductase, NAD(P)H-dependent D-xylose reductase-like protein, NAD(P)H-dependent XR, NAD(P)H-dependent xylose reductase, NAD(P)H-linked xylose reductase, NADH/NADPH-xylose reductase, NADP-dependent xylose reductase, PsXR, PsXYL1, SaXYL1, SpXYL1.1, SsXR, Texr, XR, XYL1, xylose reductase, XylR, XyrA

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.307 D-xylose reductase [NAD(P)H]

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Results	in table
8	Activating Compound
2789	AA Sequence
14	Application
22	Cloned(Commentary)
88	Cofactor
1	Crystallization (Commentary)
6	Expression
39	General Information
1	General Stability
26	Inhibitors
77	kcat/KM [mM/s]
11	Ki Value [mM]
120	KM Value [mM]
8	Localization
4	Metals/Ions
12	Molecular Weight [Da]
83	Natural Substrates/ Products (Substrates)
173	Organism
1	Oxidation Stability
2	Pathway
4	PDB ID
24	pH Optimum
10	pH Range
1	pH Stability
2	pI Value
67	Protein Variants
12	Purification (Commentary)
2	Reaction
71	Reference
1	Renatured (Commentary)
10	Source Tissue
19	Specific Activity [micromol/min/mg]
4	Storage Stability
207	Substrates and Products (Substrate)
14	Subunits
112	Synonyms
1	Systematic Name
20	Temperature Optimum [°C]
7	Temperature Range [°C]
9	Temperature Stability [°C]
95	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 1.1.1.307 - D-xylose reductase [NAD(P)H]

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2.67 - 12.86

5,6-dideoxy-5,6-difluoro-D-glucofuranose

2 entries

-

1.46 - 15

5,6-dideoxy-5-fluoro-D-glucofuranose

2 entries

-

6.9

5,6-dideoxy-6-fluoro-D-xylo-hexofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

1.43

5,6-dideoxy-6-fluoro-D-xylohexofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

36

5,6-dideoxy-D-xylo-hexofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

8.24

5,6-dideoxy-D-xylohexofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

0.35 - 1.7

5-azido-5-deoxy-D-xylofuranose

2 entries

-

10.38 - 20

5-deoxy-D-xylofuranose

2 entries

-

6.46 - 31.7

5-fluoro-5-deoxy-D-xylofuranose

2 entries

-

5.6 - 22.86

6-azido-5,6-dideoxy-5-fluoro-D-glucofuranose

2 entries

-

0.15

6-azido-5,6-dideoxy-D-xylohexofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

1.08 - 7.14

cyclohexanecarboxaldehyde

2 entries

0.027 - 0.16

D-galactose

4 entries

0.006 - 0.05

D-glucose

2 entries

0.75

D-ribose

Neurospora crassa

-

pH 6.3, 25°C

695733

0.19 - 27430

D-xylose

17 entries

0.141 - 0.75

L-arabinose

2 entries

15.2

NAD+

Yamadazyma tenuis

-

pH 7, 25°C

286260

26.9 - 83750

NADH

13 entries

30.9

NADP+

Yamadazyma tenuis

-

pH 7, 25°C

286260

6.2 - 1466000

NADPH

12 entries

0.98 - 3.9

oenanthaldehyde

2 entries

-

0.0034 - 0.023

xylitol

3 entries

2.67

5,6-dideoxy-5,6-difluoro-D-glucofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

12.86

5,6-dideoxy-5,6-difluoro-D-glucofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

1.46

5,6-dideoxy-5-fluoro-D-glucofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

15

5,6-dideoxy-5-fluoro-D-glucofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

0.35

5-azido-5-deoxy-D-xylofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

1.7

5-azido-5-deoxy-D-xylofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

10.38

5-deoxy-D-xylofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

20

5-deoxy-D-xylofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

6.46

5-fluoro-5-deoxy-D-xylofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

31.7

5-fluoro-5-deoxy-D-xylofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

5.6

6-azido-5,6-dideoxy-5-fluoro-D-glucofuranose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

22.86

6-azido-5,6-dideoxy-5-fluoro-D-glucofuranose

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

1.08

cyclohexanecarboxaldehyde

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

7.14

cyclohexanecarboxaldehyde

Yamadazyma tenuis

-

pH 7, 25°C

764095

0.027

D-galactose

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 30°C, with NADPH

761297

0.053

D-galactose

Yamadazyma tenuis

-

pH 7, 25°C

764095

0.08

D-galactose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

0.16

D-galactose

Neurospora crassa

-

pH 6.3, 25°C

695733

0.006

D-glucose

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 30°C, with NADPH

761297

0.05

D-glucose

Neurospora crassa

-

pH 6.3, 25°C

695733

0.19

D-xylose

[Candida] intermedia

-

cosubstrate NADPH, pH 7, 25°C

765140

0.2

D-xylose

Yamadazyma tenuis

O74237

pH 6.0, 25°C, cosubstrate: NADH

696522

0.21

D-xylose

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

0.21

D-xylose

Yamadazyma tenuis

-

pH 7, 25°C, cosubstrate: NADH

286260

0.21

D-xylose

[Candida] intermedia

-

cosubstrate NADH, pH 7, 25°C

765140

0.22

D-xylose

Yamadazyma tenuis

-

pH 7, 25°C

764095

0.25

D-xylose

[Candida] intermedia

-

cosubstrate NADPH, pH 7, 25°C

764945

0.296

D-xylose

Yamadazyma tenuis

-

pH 7, 25°C, cosubstrate: NADPH

286260

0.413

D-xylose

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 30°C

761297

0.53

D-xylose

[Candida] intermedia

-

cosubstrate NADH, pH 7, 25°C

764945

1.386

D-xylose

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 55°C

761297

1.8

D-xylose

Neurospora crassa

-

pH 6.3, 25°C, cosubstrate: NADPH

695733

6.2

D-xylose

Scheffersomyces stipitis

-

pH 6.0, cofactor: NADPH, mutant enzyme K270S/N272P/S271G/R276F

700009

81.7

D-xylose

Scheffersomyces stipitis

-

pH 6.0, cofactor: NADH, mutant enzyme K270S/N272P/S271G/R276F

700009

1460

D-xylose

Scheffersomyces stipitis

-

pH 6.0, cofactor: NADH, wild-type enzyme

700009

4648

D-xylose

Scheffersomyces stipitis

-

pH 6.0, cofactor: NADPH, wild-type enzyme

700009

27430

D-xylose

Candida tropicalis

A9QVV8

pH 5.5, 45°C

699505

0.141

L-arabinose

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 30°C, with NADPH

761297

0.75

L-arabinose

Neurospora crassa

-

pH 6.3, 25°C

695733

26.9

NADH

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 30°C, with D-xylose

761297

81.7

NADH

Scheffersomyces stipitis

-

pH 6.0, mutant enzyme K270S/N272P/S271G/R276F

700009

146.8

NADH

Scheffersomyces stipitis

P31867

mutant K21A, pH 6.5, 35°C

711539

297

NADH

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

410

NADH

[Candida] intermedia

-

pH 7, 25°C

765140

614

NADH

Scheffersomyces stipitis

P31867

wild-type, pH 6.5, 35°C

711539

713

NADH

Yamadazyma tenuis

-

pH 7, 25°C

286260

1271

NADH

Scheffersomyces stipitis

P31867

mutant K21A/N272D, pH 6.5, 35°C

711539

1460

NADH

Scheffersomyces stipitis

-

pH 6.0, wild-type enzyme, wild-type enzyme

700009

59920

NADH

Rasamsonia emersonii

C5J3R6

pH 6.5, 37°C, wild-type enzyme

699066

59920

NADH

Rasamsonia emersonii

C5J3R6

wild-type, pH 6.5, 37°C

699066

83750

NADH

Rasamsonia emersonii

C5J3R6

pH 6.5, 37°C, mutant enzyme K271R/N273D

699066

83750

NADH

Rasamsonia emersonii

C5J3R6

mutant K271R/N273, pH 6.5, 37°C

699066

6.2

NADPH

Scheffersomyces stipitis

-

pH 6.0, mutant enzyme K270S/N272P/S271G/R276F

700009

33.3

NADPH

Neurospora crassa

-

pH 6.3, 25°C

695733

84.4

NADPH

Thermochaetoides thermophila

G0SCE7

recombinant enzyme, pH 6.5, 30°C, with D-xylose

761297

200

NADPH

[Candida] intermedia

-

pH 7, 25°C

765140

548

NADPH

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

1592

NADPH

Scheffersomyces stipitis

P31867

wild-type, pH 6.5, 35°C

711539

4610

NADPH

Yamadazyma tenuis

-

pH 7, 25°C

286260

4648

NADPH

Scheffersomyces stipitis

-

pH 6.0, wild-type enzyme, wild-type enzyme

700009

135500

NADPH

Rasamsonia emersonii

C5J3R6

pH 6.5, 37°C, mutant enzyme K271R/N273D

699066

135500

NADPH

Rasamsonia emersonii

C5J3R6

mutant K271R/N273, pH 6.5, 37°C

699066

1466000

NADPH

Rasamsonia emersonii

C5J3R6

pH 6.5, 37°C, wild-type enzyme

699066

1466000

NADPH

Rasamsonia emersonii

C5J3R6

wild-type, pH 6.5, 37°C

699066

0.98

oenanthaldehyde

[Candida] intermedia

A0A1L0DQY1

pH 7, 25°C

764095

-

3.9

oenanthaldehyde

Yamadazyma tenuis

-

pH 7, 25°C

764095

-

0.0034

xylitol

Yamadazyma tenuis

-

pH 7, 25°C

286260

0.005

xylitol

[Candida] intermedia

-

cosubstrate NADP+, pH 7, 25°C

764945

0.023

xylitol

[Candida] intermedia

-

cosubstrate NAD+, pH 7, 25°C

764945