1.1.1.300: NADP-retinol dehydrogenase

This is an abbreviated version!
For detailed information about NADP-retinol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.300

Reaction

retinol
+
NADP+
=
retinal
+
NADPH
+
H+

Synonyms

aldehyde dehydrogenase, ALDH, all-trans retinal reductase, all-trans-retinol dehydrogenase, CG2065, CG2070, CG30491, CG3842, DHRS3, hRDH5, hRoDH, More, mouse RDH11, mRDH11, NADP(H)-dependent retinol dehydrogenase/reductase, NADP+-dependent all-trans-retinol dehydrogenase, NDRD, NRDR, NRDRA1, NRDRB1, NRDRB2, peroxisomal NADP(H)-dependent retinol dehydrogenase-reductase, photoreceptor retinol dehydrogenase, photoreceptor-associated retinol dehydrogenase, photoreceptor-specific retinol dehydrogenase, prRDH, RalR1, RDH, RDH10, RDH11, RDH12, RDH13, RDH14, RDH8, retinal reductase, retinal reductase 1, retinaldehyde reductase, retinoid dehydrogenase/reductase, Retinol dehydrogenase, retinol dehydrogenase 10, retinol dehydrogenase 11, retinol dehydrogenase 12, retinol dehydrogenase 13, retinol dehydrogenase 8, retinol dehydrogenase [NADP+], retinol dehydrogenase-10, retSDR1, RHD8, short-chain dehydrogenase/reductase RRD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.300 NADP-retinol dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.300 - NADP-retinol dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(E)-4-hydroxy-2-nonenal + NADPH + H+
(E)-4-hydroxy-2-nonenol + NADP+
show the reaction diagram
11-cis-retinal + NADH + H+
11-cis-retinol + NAD+
show the reaction diagram
NADH much less efficient than NADPH
-
-
r
11-cis-retinal + NADPH + H+
11-cis-retinol + NADP+
show the reaction diagram
11-cis-retinol + NADP+
11-cis-retinal + NADPH
show the reaction diagram
-
-
-
?
11-cis-retinol + NADP+
11-cis-retinal + NADPH + H+
show the reaction diagram
possibly involved in the production of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments
-
-
r
13-cis-retinal + NADPH
13-cis-retinol + NADP+
show the reaction diagram
-
-
-
r
13-cis-retinal + NADPH + H+
13-cis-retinol + NADP+
show the reaction diagram
-
4fold lower activity than with all-trans-retinal
-
-
?
13-cis-retinol + NADP+
13-cis-retinal + NADPH + H+
show the reaction diagram
-
-
-
r
9-cis-retinal + NADPH
9-cis-retinol + NADP+
show the reaction diagram
-
-
-
r
9-cis-retinal + NADPH + H+
9-cis-retinol + NADP+
show the reaction diagram
-
60fold lower activity than with all-trans-retinal
-
-
?
9-cis-retinol + NADP+
9-cis-retinal + NADPH + H+
show the reaction diagram
all-trans retinal + NADH + H+
all-tans-retinol + NAD+
show the reaction diagram
NADH much less efficient than NADPH
-
-
r
all-trans retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
Q7JUS1, Q7JYX2, Q8MZG9, Q9W404
prefers NADP+ and NADPH as cofactors
-
-
r
all-trans retinal + NADPH + H+
all-tans-retinol + NADP+
show the reaction diagram
-
-
-
r
all-trans retinal + NADPH + H+
all-trans-retinol + NADP+
show the reaction diagram
Q7JUS1, Q7JYX2, Q8MZG9, Q9W404
prefers NADP+ and NADPH as cofactors
-
-
r
all-trans-3-hydroxyretinal + NADH + H+
all-trans-3-hydroxyretinol + NAD+
show the reaction diagram
Q7JUS1, Q7JYX2, Q8MZG9, Q9W404
catalytic efficiency towards all-trans-3-hydroxyretinal is lower than that towards all-trans retinal, prefers NADP+ and NADPH as cofactors
-
-
?
all-trans-3-hydroxyretinal + NADPH + H+
all-trans-3-hydroxyretinol + NADP+
show the reaction diagram
Q7JUS1, Q7JYX2, Q8MZG9, Q9W404
catalytic efficiency towards all-trans-3-hydroxyretinal is lower than that towards all-trans retinal, prefers NADP+ and NADPH as cofactors
-
-
?
all-trans-retinal + NAD(P)H + H+
all-trans-retinol + NAD(P)+
show the reaction diagram
all-trans-retinal + NADH + H+
all-trans-retinol + NAD+
show the reaction diagram
all-trans-retinal + NADPH + H+
all-tans-retinol + NADP+
show the reaction diagram
all-trans-retinal + NADPH + H+
all-trans-retinol + NADP+
show the reaction diagram
all-trans-retinol + NAD+
all-trans-retinal + NADH + H+
show the reaction diagram
low activity with NAD+ as cofactor
-
-
r
all-trans-retinol + NADP+
all-trans-retinal + NADPH + H+
show the reaction diagram
cis-6-nonenal + NADPH + H+
?
show the reaction diagram
-
good substrate of RDH11 and RDH12, while RHD10 has very low activity towards this substrate
-
-
?
estrone + NADH + H+
estradiol + NAD+
show the reaction diagram
n-nonanal + NADPH + H+
n-nonanol + NADP+
show the reaction diagram
retinal + NAD+
retinoic acid + NADH + H+
show the reaction diagram
-
-
-
-
?
retinal + NADH
retinol + NAD+
show the reaction diagram
-
-
-
-
?
retinal + NADPH + H+
retinol + NADP+
show the reaction diagram
retinol + NAD+
retinal + NADH
show the reaction diagram
-
-
-
-
?
retinol + NAD+
retinal + NADH + H+
show the reaction diagram
-
-
-
-
?
retinol + NADP+
retinal + NADPH
show the reaction diagram
-
-
-
-
?
retinol + NADP+
retinal + NADPH + H+
show the reaction diagram
retinol bound to cellular retinol binding protein + NADP+
retinal bound to cellular retinol binding protein + NADPH
show the reaction diagram
-
-
-
-
-
trans-2-nonenal + NADPH + H+
?
show the reaction diagram
-
good substrate of RDH11 and RDH12, while RHD10 has very low activity towards this substrate
-
-
?
additional information
?
-