1.1.1.300: NADP-retinol dehydrogenase

This is an abbreviated version!
For detailed information about NADP-retinol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.300

Reaction

retinol
+
NADP+
=
retinal
+
NADPH
+
H+

Synonyms

aldehyde dehydrogenase, ALDH, all-trans retinal reductase, all-trans-retinol dehydrogenase, CG2065, CG2070, CG30491, CG3842, DHRS3, hRDH5, hRoDH, More, mouse RDH11, mRDH11, NADP(H)-dependent retinol dehydrogenase/reductase, NADP+-dependent all-trans-retinol dehydrogenase, NDRD, NRDR, NRDRA1, NRDRB1, NRDRB2, peroxisomal NADP(H)-dependent retinol dehydrogenase-reductase, photoreceptor retinol dehydrogenase, photoreceptor-associated retinol dehydrogenase, photoreceptor-specific retinol dehydrogenase, prRDH, RalR1, RDH, RDH10, RDH11, RDH12, RDH13, RDH14, RDH8, retinal reductase, retinal reductase 1, retinaldehyde reductase, retinoid dehydrogenase/reductase, Retinol dehydrogenase, retinol dehydrogenase 10, retinol dehydrogenase 11, retinol dehydrogenase 12, retinol dehydrogenase 13, retinol dehydrogenase 8, retinol dehydrogenase [NADP+], retinol dehydrogenase-10, retSDR1, RHD8, short-chain dehydrogenase/reductase RRD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.300 NADP-retinol dehydrogenase

Specific Activity

Specific Activity on EC 1.1.1.300 - NADP-retinol dehydrogenase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.012
-
mutant enzyme C300S, with retinal and NADPH as substrates, at pH 7.0 and 37°C
0.0386
-
mutant enzyme C300S, with retinal and NAD+ as substrates, at pH 7.0 and 37°C
0.068
-
mutant enzyme C300A, with retinal and NADPH as substrates, at pH 7.0 and 37°C
0.08
-
mutant enzyme E266A, with retinal and NADPH as substrates, at pH 7.0 and 37°C
0.136
-
wild type enzyme, with retinal and NADPH as substrates, at pH 7.0 and 37°C
0.26
-
mutant enzyme E457V, with retinal and NADPH as substrates, at pH 7.0 and 37°C
0.408
-
mutant enzyme E194S, with retinal and NADPH as substrates, at pH 7.0 and 37°C
0.461
-
wild type enzyme, with retinal and NAD+ as substrates, at pH 7.0 and 37°C
0.493
-
mutant enzyme E194S, with retinal and NAD+ as substrates, at pH 7.0 and 37°C
0.63
-
eluate after purification, the specific activity of the purified enzyme with all-trans-retinal as substrate is 13fold higher than that of the microsomal preparation of wild-type
2.536
-
mutant enzyme E457V, with retinal and NAD+ as substrates, at pH 7.0 and 37°C