1.1.1.300: NADP-retinol dehydrogenase

This is an abbreviated version!
For detailed information about NADP-retinol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.300

Reaction

retinol
+
NADP+
=
retinal
+
NADPH
+
H+

Synonyms

aldehyde dehydrogenase, ALDH, all-trans retinal reductase, all-trans-retinol dehydrogenase, CG2065, CG2070, CG30491, CG3842, DHRS3, hRDH5, hRoDH, More, mouse RDH11, mRDH11, NADP(H)-dependent retinol dehydrogenase/reductase, NADP+-dependent all-trans-retinol dehydrogenase, NDRD, NRDR, NRDRA1, NRDRB1, NRDRB2, peroxisomal NADP(H)-dependent retinol dehydrogenase-reductase, photoreceptor retinol dehydrogenase, photoreceptor-associated retinol dehydrogenase, photoreceptor-specific retinol dehydrogenase, prRDH, RalR1, RDH, RDH10, RDH11, RDH12, RDH13, RDH14, RDH8, retinal reductase, retinal reductase 1, retinaldehyde reductase, retinoid dehydrogenase/reductase, Retinol dehydrogenase, retinol dehydrogenase 10, retinol dehydrogenase 11, retinol dehydrogenase 12, retinol dehydrogenase 13, retinol dehydrogenase 8, retinol dehydrogenase [NADP+], retinol dehydrogenase-10, retSDR1, RHD8, short-chain dehydrogenase/reductase RRD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.300 NADP-retinol dehydrogenase

Reference

Reference on EC 1.1.1.300 - NADP-retinol dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Haeseleer, F.; Huang, J.; Lebiodas, L.; Saari, J.C.; Palczewski, K.
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal
J. Biol. Chem.
273
21790-21799
1998
Homo sapiens (O75911)
Manually annotated by BRENDA team
Belyaeva, O.V.; Stetsenko, A.V.; Nelson, P.; Kedishvili, N.Y.
Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines
Biochemistry
42
14838-14845
2003
Homo sapiens
Manually annotated by BRENDA team
Kedishvili, N.Y.; Chumakova, O.V.; Chetyrkin, S.V.; Belyaeva, O.V.; Lapshina, E.A.; Lin, D.W.; Matsumura, M.; Nelson, P.S.
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)
J. Biol. Chem.
277
28909-28915
2002
Homo sapiens, Homo sapiens (Q8TC12)
Manually annotated by BRENDA team
Haeseleer, F.; Jang, G.F.; Imanishi, Y.; Driessen, C.A.; Matsumura, M.; Nelson, P.S.; Palczewski, K.
Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina
J. Biol. Chem.
277
45537-45546
2002
Homo sapiens, Homo sapiens (Q96NR8), Homo sapiens (Q9HBH5)
Manually annotated by BRENDA team
Markova, N.G.; Pinkas-Sarafova, A.; Karaman-Jurukovska, N.; Jurukovski, V.; Simon, M.
Expression pattern and biochemical characteristics of a major epidermal retinol dehydrogenase
Mol. Genet. Metab.
78
119-135
2003
Homo sapiens
Manually annotated by BRENDA team
Janecke, A.R.; Thompson, D.A.; Utermann, G.; Becker, C.; Hubner, C.A.; Schmid, E.; McHenry, C.L.; Nair, A.R.; Ruschendorf, F.; Heckenlively, J.; Wissinger, B.; Nurnberg, P.; Gal, A.
Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy
Nat. Genet.
36
850-854
2004
Homo sapiens
Manually annotated by BRENDA team
Gallego, O.; Belyaeva, O.V.; Porte, S.; Ruiz, F.X.; Stetsenko, A.V.; Shabrova, E.V.; Kostereva, N.V.; Farres, J.; Pares, X.; Kedishvili, N.Y.
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids
Biochem. J.
399
101-109
2006
Homo sapiens, Homo sapiens (Q8TC12)
Manually annotated by BRENDA team
Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kim, T.; Nelson, P.S.; Kedishvili, N.Y.
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids
Biochemistry
44
7035-7047
2005
Homo sapiens, Homo sapiens (Q96NR8)
Manually annotated by BRENDA team
Maeda, A.; Maeda, T.; Imanishi, Y.; Kuksa, V.; Alekseev, A.; Bronson, J.D.; Zhang, H.; Zhu, L.; Sun, W.; Saperstein, D.A.; Rieke, F.; Baehr, W.; Palczewski, K.
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo
J. Biol. Chem.
280
18822-18832
2005
Mus musculus
Manually annotated by BRENDA team
Kasus-Jacobi, A.; Ou, J.; Birch, D.G.; Locke, K.G.; Shelton, J.M.; Richardson, J.A.; Murphy, A.J.; Valenzuela, D.M.; Yancopoulos, G.D.; Edwards, A.O.
Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo
J. Biol. Chem.
280
20413-20420
2005
Homo sapiens (O75911), Homo sapiens (Q8TC12), Homo sapiens (Q92781), Homo sapiens (Q96NR8), Homo sapiens (Q9HBH5), Homo sapiens (Q9NYR8), Mus musculus, Mus musculus (Q9QYF1)
Manually annotated by BRENDA team
Liden, M.; Eriksson, U.
Understanding retinol metabolism: Structure and function of retinol dehydrogenases
J. Biol. Chem.
281
13001-13004
2006
Bos taurus, Mus musculus
Manually annotated by BRENDA team
Maeda, A.; Maeda, T.; Imanishi, Y.; Sun, W.; Jastrzebska, B.; Hatala, D.A.; Winkens, H.J.; Hofmann, K.P.; Janssen, J.J.; Baehr, W.; Driessen, C.A.; Palczewski, K.
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice
J. Biol. Chem.
49
37697-37704
2006
Mus musculus
Manually annotated by BRENDA team
Ala-Laurila, P.; Kolesnikov, A.V.; Crouch, R.K.; Tsina, E.; Shukolyukov, S.A.; Govardovskii, V.I.; Koutalos, Y.; Wiggert, B.; Estevez, M.E.; Cornwall, M.C.
Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology
J. Gen. Physiol.
128
153-169
2006
Ambystoma tigrinum
Manually annotated by BRENDA team
Du, K.; Liu, G.F.; Xie, J.P.; Song, X.H.; Li, R.; Liang, B.; Huang, D.Y.
A 27.368 kDa retinal reductase in New Zealand white rabbit liver cytosol encoded by the peroxisomal retinol dehydrogenase-reductase cDNA: purification and characterization of the enzyme
Biochem. Cell Biol.
85
209-217
2007
Oryctolagus cuniculus, Oryctolagus cuniculus (Q9GKX2)
Manually annotated by BRENDA team
Lee, S.; Belyaeva, O.V.; Kedishvili, N.Y.
Effect of lipid peroxidation products on the activity of human retinol dehydrogenase 12 (RDH12) and retinoid metabolism
Biochim. Biophys. Acta
1782
421-425
2008
Homo sapiens
Manually annotated by BRENDA team
Belyaeva, O.V.; Korkina, O.V.; Stetsenko, A.V.; Kedishvili, N.Y.
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity
FEBS J.
275
138-147
2008
Homo sapiens, Homo sapiens (Q8NBN7)
Manually annotated by BRENDA team
Song, X.H.; Liang, B.; Liu, G.F.; Li, R.; Xie, J.P.; Du, K.; Huang, D.Y.
Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma
Int. J. Cancer
120
1618-1626
2007
Homo sapiens, Homo sapiens (Q9BTZ2)
Manually annotated by BRENDA team
Kanan, Y.; Wicker, L.D.; Al-Ubaidi, M.R.; Mandal, N.A.; Kasus-Jacobi, A.
Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress
Invest. Ophthalmol. Vis. Sci.
49
1071-1078
2008
Mus musculus, Mus musculus (Q8BYK4), Mus musculus (Q9QYF1)
Manually annotated by BRENDA team
Keller, B.; Adamski, J.
RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism
J. Steroid Biochem. Mol. Biol.
104
190-194
2007
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Maeda, A.; Maeda, T.; Sun, W.; Zhang, H.; Baehr, W.; Palczewski, K.
Redundant and unique roles of retinol dehydrogenases in the mouse retina
Proc. Natl. Acad. Sci. USA
104
19565-19570
2007
Mus musculus (Q8BYK4)
Manually annotated by BRENDA team
Lei, Z.; Chen, W.; Zhang, M.; Napoli, J.L.
Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate
Biochemistry
42
4190-4196
2003
Mus musculus
Manually annotated by BRENDA team
Belyaeva, O.V.; Lee, S.A.; Kolupaev, O.V.; Kedishvili, N.Y.
Identification and characterization of retinoid-active short-chain dehydrogenases/reductases in Drosophila melanogaster
Biochim. Biophys. Acta
1790
1266-1273
2009
Drosophila melanogaster (Q7JUS1), Drosophila melanogaster (Q7JYX2), Drosophila melanogaster (Q8MZG9), Drosophila melanogaster (Q9W404)
Manually annotated by BRENDA team
Pares, X.; Farres, J.; Kedishvili, N.; Duester, G.
Medium- and short-chain dehydrogenase/reductase gene and protein families: Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism
Cell. Mol. Life Sci.
65
3936-3949
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Yao, Y.; Han, W.; Zhou, Y.; Luo, Q.; Li, Z.
Catalytic reaction mechanism of human photoreceptor retinol dehydrogenase: A theoretical study
J. Theor. Comput. Chem.
7
565-578
2008
Homo sapiens
-
Manually annotated by BRENDA team
Marchette, L.D.; Thompson, D.A.; Kravtsova, M.; Ngansop, T.N.; Mandal, M.N.; Kasus-Jacobi, A.
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells
Free Radic. Biol. Med.
48
16-25
2010
Mus musculus, Mus musculus (Q8BYK4), Mus musculus (Q9QYF1)
Manually annotated by BRENDA team
Haller, F.; Moman, E.; Hartmann, R.W.; Adamski, J.; Mindnich, R.
Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase
J. Mol. Biol.
399
255-267
2010
Danio rerio, Homo sapiens, Homo sapiens (Q9NYR8)
Manually annotated by BRENDA team
Tsigelny, I.; Baker, M.E.
Structures important in NAD(P)(H) specificity for mammalian retinol and 11-cis-retinol dehydrogenases
Biochem. Biophys. Res. Commun.
226
118-127
1996
Rattus norvegicus
Manually annotated by BRENDA team
Lee, S.A.; Belyaeva, O.V.; Kedishvili, N.Y.
Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49M
Chem. Biol. Interact.
191
55-59
2011
Homo sapiens
Manually annotated by BRENDA team
Chen, C.; Thompson, D.A.; Koutalos, Y.
Reduction of all-trans-retinal in vertebrate rod photoreceptors requires the combined action of RDH8 and RDH12
J. Biol. Chem.
287
24662-24670
2012
Mus musculus, Mus musculus C57BL/6 x 129/Sv
Manually annotated by BRENDA team
Wang, H.; Cui, X.; Gu, Q.; Chen, Y.; Zhou, J.; Kuang, Y.; Wang, Z.; Xu, X.
Retinol dehydrogenase 13 protects the mouse retina from acute light damage
Mol. Vis.
18
1021-1030
2012
Mus musculus, Mus musculus C57BL/6 x 129/Sv
Manually annotated by BRENDA team
Adams, M.K.; Belyaeva, O.V.; Wu, L.; Kedishvili, N.Y.
The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis
J. Biol. Chem.
289
14868-14880
2014
Homo sapiens (O75911), Mus musculus (O88876), Mus musculus (Q8VCH7)
Manually annotated by BRENDA team
Obrochta, K.M.; Krois, C.R.; Campos, B.; Napoli, J.L.
Insulin regulates retinol dehydrogenase expression and all-trans-retinoic acid biosynthesis through FoxO1
J. Biol. Chem.
290
7259-7268
2015
Mus musculus (Q8VCH7)
Manually annotated by BRENDA team
Hong, S.H.; Ngo, H.P.; Nam, H.K.; Kim, K.R.; Kang, L.W.; Oh, D.K.
Alternative biotransformation of retinal to retinoic acid or retinol by an aldehyde dehydrogenase from Bacillus cereus
Appl. Environ. Microbiol.
82
3940-3946
2016
Bacillus cereus
Manually annotated by BRENDA team
Lhor, M.; Methot, M.; Horchani, H.; Salesse, C.
Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes
Biochim. Biophys. Acta
1848
878-885
2015
Homo sapiens
Manually annotated by BRENDA team
Arregi, I.; Climent, M.; Iliev, D.; Strasser, J.; Gouignard, N.; Johansson, J.K.; Singh, T.; Mazur, M.; Semb, H.; Artner, I.; Minichiello, L.; Pera, E.M.
Retinol dehydrogenase-10 regulates pancreas organogenesis and endocrine cell differentiation via paracrine retinoic acid signaling
Endocrinology
157
4615-4631
2016
Mus musculus
Manually annotated by BRENDA team
Kummalue, T.; Inoue, T.; Miura, Y.; Narusawa, M.; Inoue, H.; Komatsu, N.; Wanachiwanawin, W.; Sugiyama, D.; Tani, K.
Ribosomal protein L11- and retinol dehydrogenase 11-induced erythroid proliferation without erythropoietin in UT-7/Epo erythroleukemic cells
Exp. Hematol.
43
414-423.e1
2015
Homo sapiens
Manually annotated by BRENDA team
Jiang, W.; Napoli, J.
The retinol dehydrogenase Rdh10 localizes to lipid droplets during acyl ester biosynthesis
J. Biol. Chem.
288
589-597
2013
Mus musculus
Manually annotated by BRENDA team
Kolesnikov, A.V.; Maeda, A.; Tang, P.H.; Imanishi, Y.; Palczewski, K.; Kefalov, V.J.
Retinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina
J. Physiol.
593
4923-4941
2015
Mus musculus
Manually annotated by BRENDA team