1.1.1.300: NADP-retinol dehydrogenase

This is an abbreviated version!
For detailed information about NADP-retinol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.300

Reaction

retinol
+
NADP+
=
retinal
+
NADPH
+
H+

Synonyms

aldehyde dehydrogenase, ALDH, all-trans retinal reductase, all-trans-retinol dehydrogenase, CG2065, CG2070, CG30491, CG3842, DHRS3, hRDH5, hRoDH, More, mouse RDH11, mRDH11, NADP(H)-dependent retinol dehydrogenase/reductase, NADP+-dependent all-trans-retinol dehydrogenase, NDRD, NRDR, NRDRA1, NRDRB1, NRDRB2, peroxisomal NADP(H)-dependent retinol dehydrogenase-reductase, photoreceptor retinol dehydrogenase, photoreceptor-associated retinol dehydrogenase, photoreceptor-specific retinol dehydrogenase, prRDH, RalR1, RDH, RDH10, RDH11, RDH12, RDH13, RDH14, RDH8, retinal reductase, retinal reductase 1, retinaldehyde reductase, retinoid dehydrogenase/reductase, Retinol dehydrogenase, retinol dehydrogenase 10, retinol dehydrogenase 11, retinol dehydrogenase 12, retinol dehydrogenase 13, retinol dehydrogenase 8, retinol dehydrogenase [NADP+], retinol dehydrogenase-10, retSDR1, RHD8, short-chain dehydrogenase/reductase RRD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.300 NADP-retinol dehydrogenase

Disease

Disease on EC 1.1.1.300 - NADP-retinol dehydrogenase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Blindness
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.
Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress.
Carcinoma, Squamous Cell
Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.
Cone-Rod Dystrophies
Toll-like receptor 3 is required for development of retinopathy caused by impaired all-trans-retinal clearance in mice.
Glioma
Retinol dehydrogenase-10 promotes development and progression of human glioma via the TWEAK-NF-?B axis.
Leber Congenital Amaurosis
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.
Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress.
Macular Degeneration
Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4-/-Rdh8-/- Mice After Light Exposure.
Neoplasms
Properties of short-chain dehydrogenase/reductase RalR1: characterization of purified enzyme, its orientation in the microsomal membrane, and distribution in human tissues and cell lines.
[Abnormal expression of genes that regulate retinoid metabolism and signaling in non-small-cell lung cancer].
Retinal Dystrophies
Retinal cone and rod photoreceptor cells exhibit differential susceptibility to light-induced damage.
Retinol dehydrogenase 12 detoxifies 4-hydroxynonenal in photoreceptor cells.
Retinol dehydrogenases RDH11 and RDH12 in the mouse retina: expression levels during development and regulation by oxidative stress.
Retinitis Pigmentosa
New syndrome with retinitis pigmentosa is caused by nonsense mutations in retinol dehydrogenase RDH11.
The ciliary membrane targeting by a ternary complex comprising transportin1, Rab8 and the ciliary targeting signal.
Stargardt Disease
Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4-/-Rdh8-/- Mice After Light Exposure.
Uterine Cervical Neoplasms
Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.
Vitamin A Deficiency
Retinyl esters are elevated in progeny of retinol dehydrogenase 11 deficient dams.