1.1.1.300: NADP-retinol dehydrogenase

This is an abbreviated version!
For detailed information about NADP-retinol dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.300

Reaction

retinol
+
NADP+
=
retinal
+
NADPH
+
H+

Synonyms

aldehyde dehydrogenase, ALDH, all-trans retinal reductase, all-trans-retinol dehydrogenase, CG2065, CG2070, CG30491, CG3842, DHRS3, hRDH5, hRoDH, More, mouse RDH11, mRDH11, NADP(H)-dependent retinol dehydrogenase/reductase, NADP+-dependent all-trans-retinol dehydrogenase, NDRD, NRDR, NRDRA1, NRDRB1, NRDRB2, peroxisomal NADP(H)-dependent retinol dehydrogenase-reductase, photoreceptor retinol dehydrogenase, photoreceptor-associated retinol dehydrogenase, photoreceptor-specific retinol dehydrogenase, prRDH, RalR1, RDH, RDH10, RDH11, RDH12, RDH13, RDH14, RDH8, retinal reductase, retinal reductase 1, retinaldehyde reductase, retinoid dehydrogenase/reductase, Retinol dehydrogenase, retinol dehydrogenase 10, retinol dehydrogenase 11, retinol dehydrogenase 12, retinol dehydrogenase 13, retinol dehydrogenase 8, retinol dehydrogenase [NADP+], retinol dehydrogenase-10, retSDR1, RHD8, short-chain dehydrogenase/reductase RRD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.300 NADP-retinol dehydrogenase

Cloned

Cloned on EC 1.1.1.300 - NADP-retinol dehydrogenase

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CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
cloned as a gene regulated by the transcription factor sterol regulatory element binding proteins and previously named SCALD for short chain aldehyde reductase
expressed in COS-7 cells
-
expressed in Escherichia coli ER2566 cells
-
expressed in native, soluble form in Escherichia coli BL21-AI and as GFP-fusion protein in HeLa-cells; GFP-fusion protein in HeLa-cells
expression in CHO-K1 cells
-
expression in HEK-293 cell
expression in HeLa cell and 293T cell
expression in Sf9 cells
-
expression in Sf9 cells, HepG2 and HEK293 cells
-
expression in Sf9 cells; expression in Sf9 cells; expression in Sf9 cells; expression in Sf9 cells
Q7JUS1, Q7JYX2, Q8MZG9, Q9W404
full-length short-chain dehydrogenase/reductase cDNA expressed in Escherichia coli, truncated cDNA expressed in SF9 insect cells, enzyme belongs to the short-chain dehydrogenase/reductase superfamily
-
production of recombinant His6-tagged enzyme in insect cells
-
recombinant expression in HEK-293 cell microsomes
-
stable transfection of HEK-293 cells; stable transfection of HEK-293 cells