1.1.1.3: homoserine dehydrogenase
This is an abbreviated version!
For detailed information about homoserine dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.3
-
1.1.1.3
-
l-threonine
-
threonine-sensitive
-
corynebacterium
-
glutamicum
-
l-lysine
-
semialdehyde
-
dihydrodipicolinate
-
l-isoleucine
-
brevibacterium
-
aspartate-derived
-
2.7.2.4
-
i-homoserine
-
rhodospirillum
-
lysine-sensitive
-
lactofermentum
-
feedback-insensitive
-
feedback-resistant
-
synthesis
-
drug development
-
agriculture
-
pharmacology
- 1.1.1.3
- l-threonine
-
threonine-sensitive
- corynebacterium
- glutamicum
- l-lysine
- semialdehyde
- dihydrodipicolinate
- l-isoleucine
- brevibacterium
-
aspartate-derived
-
2.7.2.4
-
i-homoserine
-
rhodospirillum
-
lysine-sensitive
- lactofermentum
-
feedback-insensitive
-
feedback-resistant
- synthesis
- drug development
- agriculture
- pharmacology
Reaction
Synonyms
AK-HDH, AK-HSD-1, AK-HSDH, AK-HseDH, aspartate kinase-homoserine dehydrogenase, aspartokinase-homoserine dehydrogenase I, bifunctional aspartate kinase-homoserine dehydrogenase, BsHSD, HDH, hom, hom-1, Hom6, homoserine dehydrogenase 1, homoserine dehydrogenase 2, HSD, HSDH, HseDH, More, orf19.2951, PbHSD, SACOL1362, StHSD, thrA, TM_0547, TTHA0489, TtHSD
ECTree
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Reference on EC 1.1.1.3 - homoserine dehydrogenase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sainis, J.K.; Mayne, R.G.; Wallsgrove, R.M.; Lea, P.J.; Miflin, B.J.
Localisation and characterisation of homoserine dehydrogenase isolated from barley and pea leaves
Planta
152
491-496
1981
Hordeum vulgare, Pisum sativum
Krishnaswamy, S.; Bryan, J.K.
Use of monoclonal antibodies for the purification and characterization of the threonine-sensitive isozyme of maize homoserine dehydrogenase
Arch. Biochem. Biophys.
246
250-262
1986
Zea mays
Krishnaswamy, S.; Bryan, J.K.
Ligand-induced interconversions of maize homoserine dehydrogenase among different states
Arch. Biochem. Biophys.
222
449-463
1983
Zea mays
Walter, T.J.; Connelly, J.A.; Gengenbach, B.G.; Wold, F.
Isolation and characterization of two homoserine dehydrogenases from maize suspension cultures
J. Biol. Chem.
254
1349-1355
1979
Zea mays
Di Camelli, C.A.; Bryan, J.K.
Comparison of sensitive and desensitized forms of maize homoserine dehydrogenase
Plant Physiol.
65
176-183
1980
Zea mays
Wedler, F.C.; Ley, B.W.
Kinetic and regulatory mechanisms for (Escherichia coli) homoserine dehydrogenase-I
J. Biol. Chem.
268
4880-4888
1993
Escherichia coli
Grego, S.; Tricoli, D.; Di Marco, G.
Comparison of homoserine dehydrogenase from different plant sources
Phytochemistry
19
1619-1623
1980
Ricinus communis, Pisum sativum, Triticum aestivum
-
Epstein, C.C.; Datta, P.
Homoserine dehydrogenase of Rhodospirillum rubrum. Physical and chemical characterization
Eur. J. Biochem.
82
453-461
1978
Rhodospirillum rubrum
Ogilvie, J.W.; Whitaker, S.C.
Reaction of Tris with aldehydes. Effect of Tris on reactions catalyzed by homoserine dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase
Biochim. Biophys. Acta
445
525-536
1976
Escherichia coli
Aarnes, H.; Rognes, S.E.
Threonine-sensitive aspartate kinase and homoserine dehydrogenase from Pisum sativum
Phytochemistry
13
2717-2724
1974
Pisum sativum
-
Cavari, B.Z.; Grossowicz, N.
Properties of homoserine dehydrogenase in a thermophilic bacterium
Biochim. Biophys. Acta
302
183-190
1973
Thermophilic bacterium
Saiki, T.; Shinshi, H.; Arima, K.
Studies on homoserine dehydrogenase from an extreme thermophile, Thermus flavus AT-62. Partial purification and properties
J. Biochem.
74
1239-1248
1973
Thermus thermophilus
Morbach, S.; Kelle, R.; Winkels, S.; Sahm, H.; Eggeling, L.
Engineering the homoserine dehydrogenase and threonine dehydratase control points to analyse flux towards L-isoleucine in Corynebacterium glutamicum
Appl. Microbiol. Biotechnol.
45
612-620
1996
Corynebacterium glutamicum
-
Pavagi, S.; Kochhar, S.; Kochhar, V.K.; Sane, P.V.
Purification and characterization of homoserine dehydrogenase from spinach leaves
Biochem. Mol. Biol. Int.
36
649-658
1995
Spinacia oleracea
DeLaBarre, B.; Thompson, P.R.; Wright, G.D.; Berghuis, A.M.
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases
Nat. Struct. Biol.
7
238-244
2000
Saccharomyces cerevisiae (P31116), Saccharomyces cerevisiae
Yamaki, H.; Yamaguchi, M.; Imamura, H.; Suzuki, H.; Nishimura, T.; Saito, H.; Yamaguchi, H.
The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: The inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
168
837-843
1990
Saccharomyces cerevisiae
Hama, H.; Kayahara, T.; Tsuda, M.; Tsuchiya, T.
Inhibition of homoserine dehydrogenase I by L-serine in Escherichia coli
J. Biochem.
109
604-608
1991
Escherichia coli
Yumoto, N.; Kawata, Y.; Noda, S.; Tokushige, M.
Rapid purification and characterization of homoserine dehydrogenase from Saccharomyces cerevisiae
Arch. Biochem. Biophys.
285
270-275
1991
Saccharomyces cerevisiae
Angeles, T.S.; Viola, R.E.
The kinetic mechanism of the bifunctional enzyme aspartokinase - Homoserine dehydrogenase I from Escherichia coli
Arch. Biochem. Biophys.
283
96-101
1990
Escherichia coli
Jacques, S.L.; Ejim, L.J.; Wright, G.D.
Homoserine dehydrogenase from Saccharomyces cerevisiae: kinetic mechanism and stereochemistry of hydride transfer
Biochim. Biophys. Acta
1544
42-54
2001
Saccharomyces cerevisiae
Jacques, S.L.; Nieman, C.; Bareich, D.; Broadhead, G.; Kinach, R.; Honek, J.F.; Wright, G.D.
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity
Biochim. Biophys. Acta
1544
28-41
2001
Saccharomyces cerevisiae (P31116), Saccharomyces cerevisiae
Omori, K.; Komatsubara, S.
Role of serine 352 in the allosteric response of Serratia marcescens aspartokinase I-homoserine dehydrogenase I analyzed by using site-directed mutagenesis
J. Bacteriol.
175
959-965
1993
Serratia marcescens
Paris, S.; Wessel, P.M.; Dumas, R.
Overproduction, purification, and characterization of recombinant bifunctional threonine-sensitive aspartate kinase-homoserine dehydrogenase from Arabidopsis thaliana
Protein Expr. Purif.
24
105-110
2002
Arabidopsis thaliana (O81852), Arabidopsis thaliana
Paris, S.; Viemon, C.; Curien, G.; Dumas, R.
Mechanism of control of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase by threonine
J. Biol. Chem.
278
5361-5366
2003
Arabidopsis thaliana
James, C.L.; Viola, R.E.
Production and characterization of bifunctional enzymes. Domain swapping to produce new bifunctional enzymes in the aspartate pathway
Biochemistry
41
3720-3725
2002
Escherichia coli
Ejim, L.; Mirza, I.A.; Capone, C.; Nazi, I.; Jenkins, S.; Chee, G.L.; Berghuis, A.M.; Wright, G.D.
New phenolic inhibitors of yeast homoserine dehydrogenase
Bioorg. Med. Chem.
12
3825-3830
2004
Saccharomyces cerevisiae
Rognes, S.E.; Dewaele, E.; Aas, S.F.; Jacobs, M.; Frankard, V.
Transcriptional and biochemical regulation of a novel Arabidopsis thaliana bifunctional aspartate kinase-homoserine dehydrogenase gene isolated by functional complementation of a yeast hom6 mutant
Plant Mol. Biol.
51
281-294
2003
Arabidopsis thaliana, Saccharomyces cerevisiae
Curien, G.; Ravanel, S.; Robert, M.; Dumas, R.
Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms. Physiological context sets the specificity
J. Biol. Chem.
280
41178-41183
2005
Arabidopsis thaliana
Cahyanto, M.N.; Kawasaki, H.; Nagashio, M.; Fujiyama, K.; Seki, T.
Regulation of aspartokinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate synthase and dihydrodipicolinate reductase in Lactobacillus plantarum
Microbiology
152
105-112
2006
Lactiplantibacillus plantarum
Yilmaz, E.I.; Caydasi, A.K.; Ozcengiz, G.
Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus
J. Ind. Microbiol. Biotechnol.
35
1-7
2008
Streptomyces clavuligerus (Q56R01), Streptomyces clavuligerus, Streptomyces clavuligerus NRRL 3585 (Q56R01)
Park, S.D.; Lee, J.Y.; Sim, S.Y.; Kim, Y.; Lee, H.S.
Characteristics of methionine production by an engineered Corynebacterium glutamicum strain
Metab. Eng.
9
327-336
2007
Corynebacterium glutamicum
Varisi, V.A.; Camargos, L.S.; Aguiar, L.F.; Christofoleti, R.M.; Medici, L.O.; Azevedo, R.A.
Lysine biosynthesis and nitrogen metabolism in quinoa (Chenopodium quinoa): study of enzymes and nitrogen-containing compounds
Plant Physiol. Biochem.
46
11-18
2008
Chenopodium quinoa
Brautaset, T.; Jakobsen, O.M.; Degnes, K.F.; Netzer, R.; Naerdal, I.; Krog, A.; Dillingham, R.; Flickinger, M.C.; Ellingsen, T.E.
Bacillus methanolicus pyruvate carboxylase and homoserine dehydrogenase I and II and their roles for L-lysine production from methanol at 50 degrees C
Appl. Microbiol. Biotechnol.
87
951-964
2010
Bacillus methanolicus (D8WXQ1), Bacillus methanolicus (D8WXQ2), Bacillus methanolicus, Bacillus methanolicus MGA3 (D8WXQ1), Bacillus methanolicus MGA3 (D8WXQ2), Bacillus methanolicus MGA3
Schroeder, A.C.; Zhu, C.; Yanamadala, S.R.; Cahoon, R.E.; Arkus, K.A.; Wachsstock, L.; Bleeke, J.; Krishnan, H.B.; Jez, J.M.
Threonine-insensitive homoserine dehydrogenase from soybean: genomic organization, kinetic mechanism, and in vivo activity
J. Biol. Chem.
285
827-834
2010
Glycine max (O63067), Glycine max (O65027), Glycine max (Q3S3F6), Glycine max
Dong, X.; Zhao, Y.; Zhao, J.; Wang, X.
Characterization of aspartate kinase and homoserine dehydrogenase from Corynebacterium glutamicum IWJ001 and systematic investigation of L-isoleucine biosynthesis
J. Ind. Microbiol. Biotechnol.
43
873-885
2016
Corynebacterium glutamicum (P08499), Corynebacterium glutamicum, Corynebacterium glutamicum IWJ001 (P08499), Corynebacterium glutamicum IWJ001
Chen, Z.; Rappert, S.; Zeng, A.P.
Rational design of allosteric regulation of homoserine dehydrogenase by a nonnatural inhibitor L-lysine
ACS Synth. Biol.
4
126-131
2015
Corynebacterium glutamicum (P08499), Corynebacterium glutamicum
Navratna, V.; Reddy, G.; Gopal, B.
Structural basis for the catalytic mechanism of homoserine dehydrogenase
Acta Crystallogr. Sect. D
71
1216-1225
2015
Staphylococcus aureus (A0A0H2WVX4), Staphylococcus aureus, Staphylococcus aureus COL (A0A0H2WVX4)
Navratna, V.; Gopal, B.
Crystallization and preliminary X-ray diffraction studies of Staphylococcus aureus homoserine dehydrogenase
Acta Crystallogr. Sect. F
69
1216-1219
2013
Staphylococcus aureus (A0A0H2WVX4), Staphylococcus aureus, Staphylococcus aureus COL (A0A0H2WVX4)
Tomonaga, Y.; Kaneko, R.; Goto, M.; Ohshima, T.; Yoshimune, K.
Structural insight into activation of homoserine dehydrogenase from the archaeon
Biochem. Biophys. Rep.
3
14-17
2015
Sulfurisphaera tokodaii (F9VNG5), Sulfurisphaera tokodaii DSM 16993 / JCM 10545 / NBRC 100140 / 7 (F9VNG5)
Zhan, D.; Wang, D.; Min, W.; Han, W.
Exploring the molecular basis for selective binding of homoserine dehydrogenase from Mycobacterium leprae TN toward inhibitors: a virtual screening study
Int. J. Mol. Sci.
15
1826-1841
2014
Mycobacterium leprae (P46806), Mycobacterium leprae TN (P46806), Mycobacterium leprae TN
Tsai, P.W.; Chien, C.Y.; Yeh, Y.C.; Tung, L.; Chen, H.F.; Chang, T.H.; Lan, C.Y.
Candida albicans Hom6 is a homoserine dehydrogenase involved in protein synthesis and cell adhesion
J. Microbiol. Immunol. Infect.
50
863-871
2017
Candida albicans (Q5AIA2), Candida albicans, Candida albicans SC5314 / ATCC MYA-2876 (Q5AIA2)
Hayashi, J.; Inoue, S.; Kim, K.; Yoneda, K.; Kawarabayasi, Y.; Ohshima, T.; Sakuraba, H.
Crystal structures of a hyperthermophilic archaeal homoserine dehydrogenase suggest a novel cofactor binding mode for oxidoreductases
Sci. Rep.
5
11674
2015
Pyrococcus horikoshii (O58802), Pyrococcus horikoshii ATCC 700860 (O58802)
Shen, S.; Zhu, Y.; Fang, L.; Xu, J.
Heterologous expression and characterization of L200F/D215K mutant of homoserine dehydrogenase from Corynebacterium pekinense AS1.299
Wei Sheng Wu Xue Bao
54
1178-1184
2014
Corynebacterium pekinense, Corynebacterium pekinense AS1.299
Bagatin, M.C.; Pimentel, A.L.; Biavatti, D.C.; Basso, E.A.; Kioshima, E.S.; Seixas, F.A.V.; Gauze, G.F.
Targeting the homoserine dehydrogenase of Paracoccidioides species for treatment of systemic fungal infections
Antimicrob. Agents Chemother.
61
e00165-17
2017
Paracoccidioides brasiliensis (C1G1C3), Paracoccidioides brasiliensis, Paracoccidioides lutzii (C1GTZ6), Paracoccidioides lutzii, Paracoccidioides lutzii Pb01 (C1GTZ6), Paracoccidioides brasiliensis PB18 (C1G1C3)
Liu, P.; Zhang, B.; Yao, Z.H.; Liu, Z.Q.; Zheng, Y.G.
Multiplex design of the metabolic network for production of L-homoserine in Escherichia coli
Appl. Environ. Microbiol.
86
e01477-20
2020
Escherichia coli (P00561), Escherichia coli W3110 (P00561)
Ohshida, T.; Koba, K.; Hayashi, J.; Yoneda, K.; Ohmori, T.; Ohshima, T.; Sakuraba, H.
A novel bifunctional aspartate kinase-homoserine dehydrogenase from the hyperthermophilic bacterium, Thermotoga maritima
Biosci. Biotechnol. Biochem.
82
2084-2093
2018
Thermotoga maritima (Q9WZ17), Thermotoga maritima, Thermotoga maritima DSM 3109 (Q9WZ17), Thermotoga maritima ATCC 43589 (Q9WZ17), Thermotoga maritima JCM 10099 (Q9WZ17)
Akai, S.; Ikushiro, H.; Sawai, T.; Yano, T.; Kamiya, N.; Miyahara, I.
The crystal structure of homoserine dehydrogenase complexed with L-homoserine and NADPH in a closed form
J. Biochem.
165
185-195
2019
Thermus thermophilus (Q5SL04), Thermus thermophilus
Kim, D.H.; Nguyen, Q.T.; Ko, G.S.; Yang, J.K.
Molecular and enzymatic features of homoserine dehydrogenase from Bacillus subtilis
J. Microbiol. Biotechnol.
30
1905-1911
2020
Bacillus subtilis (P19582), Bacillus subtilis, Bacillus subtilis 168 (P19582)
Bueno, P.S.A.; Rodrigues, F.A.V.; Santos, J.L.; Canduri, F.; Biavatti, D.C.; Pimentel, A.L.; Bagatin, M.C.; Kioshima, E.S.; de Freitas Gauze, G.; Seixas, F.A.V.
New inhibitors of homoserine dehydrogenase from Paracoccidioides brasiliensis presenting antifungal activity
J. Mol. Model.
25
325
2019
Paracoccidioides brasiliensis (C1G1C3), Paracoccidioides brasiliensis, Paracoccidioides brasiliensis PB18 (C1G1C3)
Skwarecki, A.S.; Schielmann, M.; Martynow, D.; Kawczynski, M.; Wisniewska, A.; Milewska, M.J.; Milewski, S.
Antifungal dipeptides incorporating an inhibitor of homoserine dehydrogenase
J. Pept. Sci.
24
e3060
2018
Candida albicans (Q5AIA2), Candida albicans ATCC MYA-2876 (Q5AIA2)
Vanasi, B.; Eppakayala, L.; Malothu, R.
L-lysine production by chemical mutagenesis of homoserine dehydrogenase of ddh gene in Corynebacterium glutamicum ATCC13032
Rasayan J. Chem.
13
1245-1261
2020
Corynebacterium glutamicum (P08499), Corynebacterium glutamicum LMG 3730 (P08499), Corynebacterium glutamicum BCRC 11384 (P08499), Corynebacterium glutamicum ATCC 13032 (P08499), Corynebacterium glutamicum JCM 1318 (P08499), Corynebacterium glutamicum NCIMB 10025 (P08499), Corynebacterium glutamicum DSM 20300 (P08499)
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Ogata, K.; Yajima, Y.; Nakamura, S.; Kaneko, R.; Goto, M.; Ohshima, T.; Yoshimune, K.
Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex
Sci. Rep.
8
5749
2018
Sulfurisphaera tokodaii (F9VNG5), Sulfurisphaera tokodaii, Sulfurisphaera tokodaii DSM 16993 (F9VNG5)
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