1.1.1.290: 4-phosphoerythronate dehydrogenase

This is an abbreviated version!
For detailed information about 4-phosphoerythronate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.290

Reaction

4-phospho-D-erythronate
+
NAD+
=
(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate
+
NADH
+
H+

Synonyms

4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.290 4-phosphoerythronate dehydrogenase

Systematic Name

Systematic Name on EC 1.1.1.290 - 4-phosphoerythronate dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
4-phospho-D-erythronate:NAD+ 2-oxidoreductase
This enzyme catalyses a step in a bacterial pathway for the biosynthesis of pyridoxal 5'-phosphate. The enzyme contains a tightly-bound NAD(H) cofactor that is not re-oxidized by free NAD+. In order to re-oxidize the cofactor and restore enzyme activity, the enzyme catalyses the reduction of a 2-oxo acid (such as 2-oxoglutarate, oxaloacetate, or pyruvate) to the respective (R)-hydroxy acid [6]. cf. EC 1.1.1.399, 2-oxoglutarate reductase.