1.1.1.290: 4-phosphoerythronate dehydrogenase

This is an abbreviated version!
For detailed information about 4-phosphoerythronate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.290

Reaction

4-phospho-D-erythronate
+
NAD+
=
(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate
+
NADH
+
H+

Synonyms

4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.290 4-phosphoerythronate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.290 - 4-phosphoerythronate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxoglutarate + NAD+
D-2-hydroxyglutaric acid + NADH + H+
show the reaction diagram
2-oxoglutarate + NADH + H+
L-2-hydroxyglutarate + NAD+
show the reaction diagram
-
stereospecific reaction
-
-
?
4-phospho-D-erythronate + NAD+
(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH
show the reaction diagram
4-phospho-D-erythronate + NAD+
2-oxo-3-hydroxy-4-phospho-butanoate + NADH
show the reaction diagram
4-phospho-D-erythronate + NAD+
2-oxo-3-hydroxy-4-phospho-butanoate + NADH + H+
show the reaction diagram
-
multiple turnovers requiring 2-oxo acids for re-oxidation of NADH bound to the enzyme PdxB a coupled assay with the enzymes SerC and PdxA following in the bioyntetic pathway, overview
-
-
?
4-phospho-D-erythronate + NAD+
3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + NADH + H+
show the reaction diagram
erythronate-4-phosphate + NAD+
(3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH
show the reaction diagram
reaction in pathway leading from erythrose-4-phosphate and glutamate to nitrogen 1 and carbon 5,5', and 6 of the pyridoxine ring
-
-
?
erythronate-4-phosphate + NAD+
3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate + NADH
show the reaction diagram
-
-
-
-
?
oxaloacetic acid + NAD+
?
show the reaction diagram
-
-
-
-
?
pyruvate + NAD+
?
show the reaction diagram
-
-
-
-
?
additional information
?
-