1.1.1.290: 4-phosphoerythronate dehydrogenase
This is an abbreviated version!
For detailed information about 4-phosphoerythronate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.290
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1.1.1.290
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2-hydroxyacid
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pyridoxine
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salvage
-
dehydrogenases
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aeruginosa
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homodimeric
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pyridoxal
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5'-phosphate
- 1.1.1.290
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2-hydroxyacid
- pyridoxine
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salvage
- dehydrogenases
- aeruginosa
-
homodimeric
- pyridoxal
- 5'-phosphate
Reaction
Synonyms
4-O-phosphoerythronate dehydrogenase, D-erythronate-4-phosphate dehydrogenase, erythronate-4-phosphate dehydrogenase, More, pdx gene product, PDXB, PdxB 4PE dehydrogenase, RdxB
ECTree
1.1.1.290 4-phosphoerythronate dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.1.1.290 - 4-phosphoerythronate dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-oxoglutarate + NADH + H+
L-2-hydroxyglutarate + NAD+
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stereospecific reaction
-
-
?
4-phospho-D-erythronate + NAD+
2-oxo-3-hydroxy-4-phospho-butanoate + NADH + H+
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multiple turnovers requiring 2-oxo acids for re-oxidation of NADH bound to the enzyme PdxB a coupled assay with the enzymes SerC and PdxA following in the bioyntetic pathway, overview
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-
?
erythronate-4-phosphate + NAD+
(3R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + NADH
reaction in pathway leading from erythrose-4-phosphate and glutamate to nitrogen 1 and carbon 5,5', and 6 of the pyridoxine ring
-
-
?
erythronate-4-phosphate + NAD+
3-hydroxy-4-phospho-hydroxy-alpha-ketobutyrate + NADH
-
-
-
-
?
4-phospho-D-erythronate + NAD+
(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH
-
-
-
?
4-phospho-D-erythronate + NAD+
(3R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH
the enzyme is involved in biosynthesis of pyridoxal-5'-phosphate
-
-
?
4-phospho-D-erythronate + NAD+
2-oxo-3-hydroxy-4-phospho-butanoate + NADH
-
-
-
-
?
4-phospho-D-erythronate + NAD+
2-oxo-3-hydroxy-4-phospho-butanoate + NADH
-
-
-
-
?
4-phospho-D-erythronate + NAD+
3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + NADH + H+
-
-
-
-
r
4-phospho-D-erythronate + NAD+
3-hydroxy-2-oxo-4-(phosphonooxy)butanoate + NADH + H+
-
-
-
-
r
additional information
?
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pdxB is the first gene in the pdxB-hisT operon
-
-
?
additional information
?
-
the enzyme mediates a step in the biosynthesis of the coenzyme pyridoxal 5'-phosphate. Transcription of pdxB gene is positively growth rate regulated. PdxB-specific transcript remains unchanged during amino acid starvation in wild-type and relA mutant strains
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-
?
additional information
?
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-
2,6-dichloroindolphenol, N-nitrosodimethylamine, and methylene blue cannot be reduced in the presence of the enzyme and 4-phospho-D-erythronate
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-
?
additional information
?
-
-
2-oxoglutarate, oxaloacetic acid, and pyruvate are equally good subtrates for the enzyme
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-
?
additional information
?
-
-
2,6-dichloroindolphenol, N-nitrosodimethylamine, and methylene blue cannot be reduced in the presence of the enzyme and 4-phospho-D-erythronate
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-
?
additional information
?
-
-
2-oxoglutarate, oxaloacetic acid, and pyruvate are equally good subtrates for the enzyme
-
-
?
additional information
?
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active site and ligand binding structure, overview
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-
?
additional information
?
-
-
active site and ligand binding structure, overview
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-
?
