1.1.1.283: methylglyoxal reductase (NADPH)

This is an abbreviated version, for detailed information about methylglyoxal reductase (NADPH), go to the full flat file.

Reaction

(S)-lactaldehyde
+
NADP+
=
2-oxopropanal
+
NADPH
+
H+

Synonyms

1.1.1.78, AKR, aldo-keto reductase, D-lactaldehyde dehydrogenase, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, MeGR, methylglyoxal reductase, methylglyoxal reductase (NADPH dependent), methylglyoxal/isovaleraldehyde reductase, More, NADPH-dependent methylglyoxal reductase, SakR1, YGL039w1, YGL039w2, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.283 methylglyoxal reductase (NADPH)

Substrates Products

Substrates Products on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-lactaldehyde + NADP+
methylglyoxal + NADPH + H+
show the reaction diagram
-
-
-
-
r
2-nitrobenzaldehyde + NADPH
2-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
3-nitrobenzaldehyde + NADPH + H+
3-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH + H+
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
acetaldehyde + NADPH + H+
ethanol + NADP+
show the reaction diagram
benzaldehyde + NADPH
benzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
crotonaldehyde + NADPH
(2Z)-but-2-en-1-ol + NADP+
show the reaction diagram
-
-
-
-
?
D-arabinose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-galactose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-glucose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
diacetyl + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
dihydroxyacetone + NADPH
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
DL-glyceraldehyde + NADPH
glycerol + NADP+
show the reaction diagram
-
-
-
-
?
ethyl (2R)-2-methyl-3-oxobutanoate + NADPH + H+
ethyl (2R,3S)-3-hydroxy-2-methylbutanoate + NADP+
show the reaction diagram
-
-
86% yield, 70% (2R,3S)-enantiomer in a strain lacking fatty acid synthase activity and overexpressing Gre2
-
?
ethyl 3-oxobutanoate + NADPH + H+
ethyl (3S)-3-hydroxybutanoate + NADP+
show the reaction diagram
-
-
83% yield, 98% S-enantiomer in a strain lacking fatty acid synthase activity and overexpressing Gre2
-
?
ethyl 3-oxohexanoate + NADPH + H+
ethyl (3S)-3-hydroxyhexanoate + NADP+
show the reaction diagram
-
-
90% yield, 98% S-enantiomer in a strain lacking fatty acid synthase activity and overexpressing Gre2
-
?
ethyl 3-oxopentanoate + NADPH + H+
ethyl (3S)-3-hydroxypentanoate + NADP+
show the reaction diagram
-
-
87% yield, 98% S-enantiomer in a strain lacking fatty acid synthase activity and overexpressing Gre2
-
?
glyoxal + NADPH
glycolaldehyde + NADP+
show the reaction diagram
heptanal + NADPH + H+
heptan-1-ol + NADP+
show the reaction diagram
isatin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
isopentaldehyde + NADPH + H+
isopentanol + NADP+
show the reaction diagram
-
-
-
-
?
isovaleraldehyde + NADPH + H+
isoamyl alcohol + NADP+
show the reaction diagram
methyl 3-oxobutanoate + NADPH + H+
methyl (3S)-3-hydroxybutanoate + NADP+
show the reaction diagram
-
-
76% yield, 98% S-enantiomer in a strain lacking fatty acid synthase activity and overexpressing Gre2
-
?
methyl 3-oxopentanoate + NADPH + H+
methyl (3S)-3-hydroxypentanoate + NADP+
show the reaction diagram
-
-
85% yield, 98% S-enantiomer in a strain lacking fatty acid synthase activity and overexpressing Gre2
-
?
methyl glyoxal + NADPH + H+
? + NADP+
show the reaction diagram
methylglyoxal + NADPH
lactaldehyde + NADP+
show the reaction diagram
methylglyoxal + NADPH + H+
(R)-lactataldehyde + NADP+
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADPH + H+
(S)-lactaldehyde + NADP+
show the reaction diagram
-
-
-
-
r
methylglyoxal + NADPH + H+
L-lactaldehyde + NADP+
show the reaction diagram
methylglyoxal + NADPH + H+
lactaldehyde + NADP+
show the reaction diagram
-
-
-
-
?
ninhydrin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
octanal + NADPH + H+
octan-1-ol + NADP+
show the reaction diagram
p-anisaldehyde + NADPH + H+
p-anisalcohol + NADP+
show the reaction diagram
-
-
-
ir
pentanal + NADPH + H+
pentan-1-ol + NADP+
show the reaction diagram
-
-
-
ir
phenylglyoxal + NADPH
hydroxyphenylacetaldehyde + NADP+
show the reaction diagram
propionaldehyde + NADPH
propanol + NADP+
show the reaction diagram
-
enzyme MGR II
-
-
?
succinic semialdehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
valeraldehyde + NADPH + H+
amyl alcohol + NADP+
show the reaction diagram
-
-
-
ir
additional information
?
-