1.1.1.283: methylglyoxal reductase (NADPH)

This is an abbreviated version, for detailed information about methylglyoxal reductase (NADPH), go to the full flat file.

Reaction

(S)-lactaldehyde
+
NADP+
=
2-oxopropanal
+
NADPH
+
H+

Synonyms

1.1.1.78, AKR, aldo-keto reductase, D-lactaldehyde dehydrogenase, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, MeGR, methylglyoxal reductase, methylglyoxal reductase (NADPH dependent), methylglyoxal/isovaleraldehyde reductase, More, NADPH-dependent methylglyoxal reductase, SakR1, YGL039w1, YGL039w2, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.283 methylglyoxal reductase (NADPH)

Reference

Reference on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Murata, K.; Fukuda, Y.; Simosaka, M.; Watanabe, K.; Saikusa, T.; Kimura, A.
Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae
Eur. J. Biochem.
151
631-636
1985
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Murata, K.; Fukuda, Y.; Shimosaka, M.; Watanabe, K.; Saikusa, T.; Kimura, A.
Phenotypic character of the methylglyoxal resistance gene in Saccharomyces cerevisiae: expression in Escherichia coli and application to breeding wild-type yeast strains
Appl. Environ. Microbiol.
50
1200-1207
1985
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Murata, K.; Inoue, Y.; Saikusa, T.; Watanabe, K.; Fukuda, Y.; Shimosaka, M.; Kimura, A.
Metabolism of alpha-ketoglutarate in yeasts: inducible formation of methylglyoxal reductase and its relation to growth arrest of Saccharomyces cerevisiae
J. Ferment. Technol.
64
1-4
1986
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Inoue, Y.; Rhee, H.; Watanabe, K.; Murata, K.; Kimura, A.
Metabolism of 2-oxoaldehyde in mold. Purification and characterization of two methylglyoxal reductases from Aspergillus niger
Eur. J. Biochem.
171
213-218
1988
Aspergillus niger
Manually annotated by BRENDA team
Inoue, Y.; Tran Linh, T.; Yoshikawa, K.; Murata, K.; Kimura, A.
Purification and characterization of methylglyoxal reductase from Hansenula mrakii
J. Ferment. Bioeng.
71
134-136
1991
Cyberlindnera mrakii
-
Manually annotated by BRENDA team
Chen, C.N.; Porubleva, L.; Shearer, G.; Svrakic, M.; Holden, L.G.; Dover, J.L.; Johnston, M.; Chitnis, P.R.; Kohl, D.H.
Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae
Yeast
20
545-554
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Xu, D.; Liu, X.; Guo, C.; Zhao, J.
Methylglyoxal detoxification by an aldo-keto reductase in the cyanobacterium Synechococcus sp. PCC 7002
Microbiology
152
2013-2021
2006
Synechococcus sp.
Manually annotated by BRENDA team
Hauser, M.; Horn, P.; Tournu, H.; Hauser, N.C.; Hoheisel, J.D.; Brown, A.J.; Dickinson, J.R.
A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase
FEMS Yeast Res.
7
84-92
2007
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Greig, N.; Wyllie, S.; Patterson, S.; Fairlamb, A.H.
A comparative study of methylglyoxal metabolism in trypanosomatids
FEBS J.
276
376-386
2009
Leishmania major, Leishmania major Friedlin, Trypanosoma brucei, Trypanosoma cruzi
Manually annotated by BRENDA team
Breicha, K.; Mueller, M.; Hummel, W.; Niefind, K.
Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae
Acta Crystallogr. Sect. F
66
838-841
2010
Saccharomyces cerevisiae (Q12068)
Manually annotated by BRENDA team
Akita, H.; Watanabe, M.; Suzuki, T.; Nakashima, N.; Hoshino, T.
Molecular cloning and characterization of two YGL039w genes encoding broad specificity NADPH-dependent aldehyde reductases from Kluyveromyces marxianus strain DMB1
FEMS Microbiol. Lett.
362
fnv116
2015
Kluyveromyces marxianus (A0A0E4AX59), Kluyveromyces marxianus (A0A0E4AY21), Kluyveromyces marxianus, Kluyveromyces marxianus DMB1 (A0A0E4AX59), Kluyveromyces marxianus DMB1 (A0A0E4AY21)
Manually annotated by BRENDA team
Guo, P.C.; Bao, Z.Z.; Ma, X.X.; Xia, Q.; Li, W.F.
Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2
Biochim. Biophys. Acta
1844
1486-1492
2014
Saccharomyces cerevisiae (Q12068), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Rodriguez, S.; Kayser, M.M.; Stewart, J.D.
Highly stereoselective reagents for beta-keto ester reductions by genetic engineering of bakers yeast
J. Am. Chem. Soc.
123
1547-1555
2001
Saccharomyces cerevisiae (Q12068)
Manually annotated by BRENDA team
Warringer, J.; Blomberg, A.
Involvement of yeast YOL151W/GRE2 in ergosterol metabolism
Yeast
23
389-398
2006
Saccharomyces cerevisiae (Q12068)
Manually annotated by BRENDA team
Guo, P.C.; Bao, Z.Z.; Ma, X.X.; Xia, Q.; Li, W.F.
Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2
Biochim. Biophys. Acta
1844
1486-1492
2014
Saccharomyces cerevisiae (Q12068), Saccharomyces cerevisiae
Manually annotated by BRENDA team