1.1.1.283: methylglyoxal reductase (NADPH)

This is an abbreviated version, for detailed information about methylglyoxal reductase (NADPH), go to the full flat file.

Reaction

(S)-lactaldehyde
+
NADP+
=
2-oxopropanal
+
NADPH
+
H+

Synonyms

1.1.1.78, AKR, aldo-keto reductase, D-lactaldehyde dehydrogenase, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, MeGR, methylglyoxal reductase, methylglyoxal reductase (NADPH dependent), methylglyoxal/isovaleraldehyde reductase, More, NADPH-dependent methylglyoxal reductase, SakR1, YGL039w1, YGL039w2, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.283 methylglyoxal reductase (NADPH)

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
isovaleraldehyde + NADPH + H+
isoamyl alcohol + NADP+
show the reaction diagram
-
catalytic mechanism involving Ser127, Tyr165, and Lys169, overview. The carbonyl oxygen interactswith the side chain of Ser127, Tyr165 through hydrogen bonds (about 2.7 A), giving a distance of 3.0 A between the C4 atom of the nicotinamide and the carbonyl carbon of substrate
-
-
?
methylglyoxal + NADPH
lactaldehyde + NADP+
show the reaction diagram
methylglyoxal + NADPH + H+
(S)-lactaldehyde + NADP+
show the reaction diagram
-
-
-
-
r
additional information
?
-
-
important role in the suppression of filamentation in response to isoamyl alcohol
-
-
-