1.1.1.283: methylglyoxal reductase (NADPH)

This is an abbreviated version, for detailed information about methylglyoxal reductase (NADPH), go to the full flat file.

Reaction

(S)-lactaldehyde
+
NADP+
=
2-oxopropanal
+
NADPH
+
H+

Synonyms

1.1.1.78, AKR, aldo-keto reductase, D-lactaldehyde dehydrogenase, Gre2, GRE2 gene product, GRE2/YOL151W, Gre2p, MeGR, methylglyoxal reductase, methylglyoxal reductase (NADPH dependent), methylglyoxal/isovaleraldehyde reductase, More, NADPH-dependent methylglyoxal reductase, SakR1, YGL039w1, YGL039w2, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.283 methylglyoxal reductase (NADPH)

General Information

General Information on EC 1.1.1.283 - methylglyoxal reductase (NADPH)

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
-
the enzyme belongs to the short-chain dehydrogenase/reductase (SDR) superfamily, which includes various oxidoreductases, some isomerases and lyases
physiological function
additional information
-
Gre2 forms a homodimer, each subunit of which contains an N-terminal Rossmann-fold domain and a variable C-terminal domain, which participates in substrate recognition. The induced fit upon binding to the cofactor NADPH makes the two domains shift toward each other, producing an interdomain cleft that better fits the substrate. The substrate-binding pocket structure determines the stringent substrate stereoselectivity for catalysis