1.1.1.278: 3beta-hydroxy-5alpha-steroid dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxy-5alpha-steroid dehydrogenase, go to the full flat file.

Reaction

Show molfile — 3beta-hydroxy-5alpha-pregnane-20-one

Synonyms

3beta-HSD/isomerase, 3beta-hydroxy steroid dehydrogenase, 3beta-hydroxy-steroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid oxidoreductase, 3beta-hydroxysteroid-5alpha-oxidoreductase, dehydrogenase, 3(17)beta-hydroxy steroid, More

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.278 3beta-hydroxy-5alpha-steroid dehydrogenase

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All data fields related to EC 1.1.1.278
Results	in table
2	Activating Compound
1	CAS Registry Number
18	Cofactor
12	Inhibitors
4	Ki Value [mM]
2	KM Value [mM]
12	Localization
10	Natural Substrates/ Products (Substrates)
14	Organism
1	Pathway
3	pH Optimum
1	pH Range
1	Reaction
3	Reaction Type
13	Reference
16	Source Tissue
3	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
10	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]

Inhibitors

Inhibitors on EC 1.1.1.278 - 3beta-hydroxy-5alpha-steroid dehydrogenase

for references in articles please use BRENDA:EC1.1.1.278

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2-mercaptoethanol

Digitalis lanata

activates at 1 mM, inhibitory at 10 mM

639087

5alpha-pregnan-3,20-dione

ascorbate

Ca2+

Co2+

L-cysteine

1 mM, together with 2-mercaptoethanl, up to 50% inhibition

Mg2+

Mn2+

NADPH

inhibitory at concentrations above 1 mM

progesterone

Zn2+

additional information

Aspergillus tamarii

presence of C-7 allylic hydroxylation, in either epimeric form, inhibits 3beta-HSD/isomerase activity

691108