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1.1.1.265: 3-methylbutanal reductase

This is an abbreviated version!
For detailed information about 3-methylbutanal reductase, go to the full flat file.

Word Map on EC 1.1.1.265

Reaction

3-Methylbutanol
+
NAD(P)+
=
3-Methylbutanal
+
NAD(P)H
+
H+

Synonyms

3-methylbutyraldehyde reductase, aldehyde reductase, bcADH, branched-chain alcohol dehydrogenase, Gre2, GRE2 gene product, Gre2p, isoamylaldehyde reductase, isopentanal reductase, isovaleral reductase, isovaleraldehyde reductase, More, protein YIM1, YIM1, YMR152W, Ymr152wp, YOL151W, YOL151w gene product

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.265 3-methylbutanal reductase

General Information

General Information on EC 1.1.1.265 - 3-methylbutanal reductase

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
physiological function
in strains lacking Gre2 activity, which are subjected to environmental stress straining the cell membrane, growth is significantly and exclusively reduced. No compensatory mechanisms are activated due to loss of Gre2p during growth in favourable conditions (synthetic defined media, no stress), but a striking and highly specific induction of the ergosterol biosynthesis pathway, enzymes Erg10, Erg19 and Erg6, is observed in Gre2 mutant strains during growth in a stress conditions in which lack of Gre2 significantly affects growth. Mutant strains display vastly impaired tolerance exclusively to agents targeting the ergosterol biosynthesis