1.1.1.262: 4-hydroxythreonine-4-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about 4-hydroxythreonine-4-phosphate dehydrogenase, go to the full flat file.

Reaction

4-phosphooxy-L-threonine
+
NAD+
=
3-amino-2-oxopropyl phosphate
+
CO2
+
NADH
+
H+

Synonyms

4-(phosphohydroxy)-L-threonine dehydrogenase, L-threonine 4-phosphate dehydrogenase, NAD-dependent threonine 4-phosphate dehydrogenase, PdxA

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.262 4-hydroxythreonine-4-phosphate dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.262 - 4-hydroxythreonine-4-phosphate dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-amino-3-oxo-4-phosphonooxybutyrate + H2O
3-amino-1-hydroxyacetone 1-phosphate + CO2
show the reaction diagram
step 2 of the overall reaction
i.e. AHAP
-
?
4-(phosphohydroxy)-L-threonine + NAD+
2-amino-3-oxo-4-phosphohydroxybutyrate + NADH
show the reaction diagram
4-(phosphohydroxy)-L-threonine + NAD+
3-phosphohydroxy-1aminoacetone + CO2 + NADH + H+
show the reaction diagram
-
involved in pyridoxal 5'-phosphate formation
further condensation with 1-deoxy-D-xylulose-5-phosphate to form pyridoxal 5'-phosphate
r
4-(phosphonooxy)threonine + NAD(P)+
2-amino-3-oxo-4-phosphonooxybutyrate + NAD(P)H
show the reaction diagram
4-(phosphonooxy)threonine + NAD(P)+
3-amino-1-hydroxyacetone 1-phosphate + CO2 + NAD(P)H
show the reaction diagram