1.1.1.261: sn-glycerol-1-phosphate dehydrogenase
This is an abbreviated version!
For detailed information about sn-glycerol-1-phosphate dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.261
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1.1.1.261
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phospholipids
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ether
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methanobacterium
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sn-glycerol-3-phosphate
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dihydroxyacetone
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thermoautotrophicum
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dehydrogenases
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hyperthermophilic
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methanogen
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isoprenoid
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dhap
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speciation
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stereochemistry
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archaea-specific
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aeropyrum
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dihydroxyacetonephosphate
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nadp+
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methanothermobacter
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pernix
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analysis
- 1.1.1.261
- phospholipids
- ether
-
methanobacterium
- sn-glycerol-3-phosphate
- dihydroxyacetone
- thermoautotrophicum
- dehydrogenases
-
hyperthermophilic
-
methanogen
-
isoprenoid
- dhap
-
speciation
-
stereochemistry
-
archaea-specific
-
aeropyrum
- dihydroxyacetonephosphate
- nadp+
-
methanothermobacter
- pernix
- analysis
Reaction
Synonyms
EgsA, Enantiomeric glycerophosphate synthase, G-1-P dehydrogenase, G-1-P-dehydrogenase, G1PDH, Gro1PDH, NAD(P)H-dependent G1P dehydrogenase, sn-glycerol-1-phosphate dehydrogenase, ST0344 protein, Zn2+-dependent sn-glycerol-1-phosphate dehydrogenase
ECTree
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Systematic Name
Systematic Name on EC 1.1.1.261 - sn-glycerol-1-phosphate dehydrogenase
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sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase
This enzyme is found primarily as a Zn2+-dependent form in Archaea but a Ni2+-dependent form has been found in Gram-positive bacteria [6]. The Zn2+-dependent metalloenzyme is responsible for the formation of Archaea-specific sn-glycerol-1-phosphate, the first step in the biosynthesis of polar lipids in Archaea. It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase) and EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase), which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [4]. Activity of the enzyme is stimulated by K+ [2].