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1.1.1.261: sn-glycerol-1-phosphate dehydrogenase

This is an abbreviated version!
For detailed information about sn-glycerol-1-phosphate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.261

Reaction

sn-glycerol 1-phosphate
+
NAD(P)+
=
glycerone phosphate
+
NAD(P)H
+
H+

Synonyms

EgsA, Enantiomeric glycerophosphate synthase, G-1-P dehydrogenase, G-1-P-dehydrogenase, G1PDH, Gro1PDH, NAD(P)H-dependent G1P dehydrogenase, sn-glycerol-1-phosphate dehydrogenase, ST0344 protein, Zn2+-dependent sn-glycerol-1-phosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.261 sn-glycerol-1-phosphate dehydrogenase

Systematic Name

Systematic Name on EC 1.1.1.261 - sn-glycerol-1-phosphate dehydrogenase

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SYSTEMATIC NAME
IUBMB Comments
sn-glycerol-1-phosphate:NAD(P)+ 2-oxidoreductase
This enzyme is found primarily as a Zn2+-dependent form in Archaea but a Ni2+-dependent form has been found in Gram-positive bacteria [6]. The Zn2+-dependent metalloenzyme is responsible for the formation of Archaea-specific sn-glycerol-1-phosphate, the first step in the biosynthesis of polar lipids in Archaea. It is the enantiomer of sn-glycerol 3-phosphate, the form of glycerophosphate found in bacteria and eukaryotes. The other enzymes involved in the biosynthesis of polar lipids in Archaea are EC 2.5.1.41 (phosphoglycerol geranylgeranyltransferase) and EC 2.5.1.42 (geranylgeranylglycerol-phosphate geranylgeranyltransferase), which together alkylate the hydroxy groups of glycerol 1-phosphate to give unsaturated archaetidic acid, which is acted upon by EC 2.7.7.67 (CDP-archaeol synthase) to form CDP-unsaturated archaeol. The final step in the pathway involves the addition of L-serine, with concomitant removal of CMP, leading to the production of unsaturated archaetidylserine [4]. Activity of the enzyme is stimulated by K+ [2].